Praseeda Mullasseril
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Explore the profile of Praseeda Mullasseril including associated specialties, affiliations and a list of published articles.
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9
Citations
330
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Recent Articles
1.
Zimmerman S, Khatri A, Garnier-Amblard E, Mullasseril P, Kurtkaya N, Gyoneva S, et al.
J Med Chem
. 2015 Mar;
58(6):2862.
PMID: 25738634
No abstract available.
2.
Zimmerman S, Khatri A, Garnier-Amblard E, Mullasseril P, Kurtkaya N, Gyoneva S, et al.
J Med Chem
. 2014 Feb;
57(6):2334-56.
PMID: 24512267
NMDA receptors are tetrameric complexes composed of GluN1 and GluN2A-D subunits that mediate a slow Ca(2+)-permeable component of excitatory synaptic transmission. NMDA receptors have been implicated in a wide range...
3.
Acker T, Yuan H, Hansen K, Vance K, Ogden K, Jensen H, et al.
Mol Pharmacol
. 2011 Aug;
80(5):782-95.
PMID: 21807990
The compound 4-(5-(4-bromophenyl)-3-(6-methyl-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid (DQP-1105) is a representative member of a new class of N-methyl-d-aspartate (NMDA) receptor antagonists. DQP-1105 inhibited GluN2C- and GluN2D-containing receptors with IC(50) values that were at...
4.
Mullasseril P, Hansen K, Vance K, Ogden K, Yuan H, Kurtkaya N, et al.
Nat Commun
. 2010 Oct;
1:90.
PMID: 20981015
NMDA receptors are tetrameric complexes of NR1 and NR2A-D subunits that mediate excitatory synaptic transmission and have a role in neurological disorders. In this article, we identify a novel subunit-selective...
5.
Mosley C, Acker T, Hansen K, Mullasseril P, Andersen K, Le P, et al.
J Med Chem
. 2010 Aug;
53(15):5476-90.
PMID: 20684595
We describe a new class of subunit-selective antagonists of N-methyl D-aspartate (NMDA)-selective ionotropic glutamate receptors that contain the (E)-3-phenyl-2-styrylquinazolin-4(3H)-one backbone. The inhibition of recombinant NMDA receptor function induced by these...
6.
Hansen K, Mullasseril P, Dawit S, Kurtkaya N, Yuan H, Vance K, et al.
J Pharmacol Exp Ther
. 2010 Mar;
333(3):650-62.
PMID: 20197375
N-Methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels that mediate a slow, Ca(2+)-permeable component of excitatory synaptic transmission in the central nervous system and play a pivotal role in synaptic plasticity,...
7.
Mosley C, Myers S, Murray E, Santangelo R, Tahirovic Y, Kurtkaya N, et al.
Bioorg Med Chem
. 2009 Aug;
17(17):6463-80.
PMID: 19648014
The synthesis and structure-activity relationship analysis of a novel class of amide-based biaryl NR2B-selective NMDA receptor antagonists are presented. Some of the studied compounds are potent, selective, non-competitive, and voltage-independent...
8.
Mullasseril P, Dosemeci A, Lisman J, Griffith L
J Neurochem
. 2007 Sep;
103(1):357-64.
PMID: 17877639
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is activated by Ca(2+) entry into neurons. Autophosphorylation of T286 is of special importance because it makes the enzyme active in the absence of Ca(2+),...
9.
Hodge J, Mullasseril P, Griffith L
Neuron
. 2006 Aug;
51(3):327-37.
PMID: 16880127
The ability of CaMKII to act as a molecular switch, becoming Ca(2+) independent after activation and autophosphorylation at T287, is critical for experience-dependent plasticity. Here, we show that the Drosophila...