Prasanna Parasuraman
Overview
Explore the profile of Prasanna Parasuraman including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
302
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Recent Articles
1.
Maruvka Y, Mouw K, Karlic R, Parasuraman P, Kamburov A, Polak P, et al.
Nat Biotechnol
. 2017 Sep;
35(10):951-959.
PMID: 28892075
Microsatellites (MSs) are tracts of variable-length repeats of short DNA motifs that exhibit high rates of mutation in the form of insertions or deletions (indels) of the repeated motif. Despite...
2.
Rheinbay E, Parasuraman P, Grimsby J, Tiao G, Engreitz J, Kim J, et al.
Nature
. 2017 Jun;
547(7661):55-60.
PMID: 28658208
Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the basis of the presence of mutations in protein-coding regions. By contrast, much less is...
3.
Parasuraman P, Mulligan P, Walker J, Li B, Boukhali M, Haas W, et al.
J Biol Chem
. 2016 Dec;
292(7):2679-2689.
PMID: 28007963
The negative regulator of Rho family GTPases, p190A RhoGAP, is one of six mammalian proteins harboring so-called FF motifs. To explore the function of these and other p190A segments, we...
4.
Kanagaraj R, Parasuraman P, Mihaljevic B, van Loon B, Burdova K, Konig C, et al.
Nucleic Acids Res
. 2012 Jul;
40(17):8449-59.
PMID: 22753033
Reactive oxygen species constantly generated as by-products of cellular metabolism readily attack genomic DNA creating mutagenic lesions such as 7,8-dihydro-8-oxo-guanine (8-oxo-G) that promote aging. 8-oxo-G:A mispairs arising during DNA replication...
5.
Mishra S, Karmodiya K, Parasuraman P, Surolia A, Surolia N
Bioorg Med Chem
. 2008 Apr;
16(10):5536-46.
PMID: 18434169
A number of new triclosan-conjugated analogs bearing biodegradable ester linkage have been synthesized, characterized and evaluated for their antimalarial and antibacterial activities. Many of these compounds exhibit good inhibition against...
6.
Kumar G, Parasuraman P, Sharma S, Banerjee T, Karmodiya K, Surolia N, et al.
J Med Chem
. 2007 May;
50(11):2665-75.
PMID: 17477517
Enoyl acyl carrier protein (ACP) reductase, one of the enzymes of the type II fatty acid biosynthesis pathway, has been established as a promising target for the development of new...
7.
Sharma S, Parasuraman P, Kumar G, Surolia N, Surolia A
J Med Chem
. 2007 Feb;
50(4):765-75.
PMID: 17263522
We have investigated the mechanism of inhibition of enoyl-acyl carrier protein reductase of Plasmodium falciparum (PfENR) by triclosan in the presence of a few important catechins and related plant polyphenols....
8.
Chhibber M, Kumar G, Parasuraman P, Ramya T, Surolia N, Surolia A
Bioorg Med Chem
. 2006 Aug;
14(23):8086-98.
PMID: 16893651
We designed some novel diphenyl ethers and determined their binding energies for Enoyl-Acyl Carrier Protein Reductase (ENR) of Plasmodium falciparum using Autodock. Out of these, we synthesized the promising compounds...