Praneeth D Edirisinghe
Overview
Explore the profile of Praneeth D Edirisinghe including associated specialties, affiliations and a list of published articles.
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12
Citations
100
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Recent Articles
1.
Frankenberger C, Borgia J, Edirisinghe P, Oegema T
Connect Tissue Res
. 2012 Dec;
54(2):123-31.
PMID: 23237500
Aggrecan is the prominent proteoglycan in cartilage and is modified with approximately 100 chondroitin sulfate (CS) chains through a tetrasaccharide linkage structure. In osteoarthritis (OA), the viscoelastic properties of cartilage...
2.
Blaze M T M, Akhmetov A, Aydin B, Edirisinghe P, Uygur G, Hanley L
Anal Chem
. 2012 Sep;
84(21):9410-5.
PMID: 23017064
The potential of laser desorption postionization mass spectrometry (LDPI-MS) imaging for small molecule quantification is demonstrated here. The N-methylpiperazine acetamide (MPA) of ampicillin was adsorbed into polyelectrolyte multilayer surface coatings...
3.
Kastrati I, Edirisinghe P, Hemachandra L, Chandrasena E, Choi J, Wang Y, et al.
PLoS One
. 2011 Dec;
6(11):e27876.
PMID: 22140478
There is association between exposure to estrogens and the development and progression of hormone-dependent gynecological cancers. Chemical carcinogenesis by catechol estrogens derived from oxidative metabolism is thought to contribute to...
4.
Kastrati I, Edirisinghe P, Wijewickrama G, Thatcher G
Endocrinology
. 2010 Oct;
151(12):5602-16.
PMID: 20943808
Estrogen action, via both nuclear and extranuclear estrogen receptors (ERs), induces a variety of cellular signals that are prosurvival or proliferative, whereas nitric oxide (NO) can inhibit apoptosis via caspase...
5.
Sinha V, Wijewickrama G, Chandrasena R, Xu H, Edirisinghe P, Schiefer I, et al.
ACS Chem Biol
. 2010 Jun;
5(7):667-80.
PMID: 20524644
Protein S-nitrosation has been argued to be the most important signaling pathway mediating the bioactivity of NO. This post-translational modification of protein thiols is the result of chemical nitrosation of...
6.
Hagos G, Abdul-Hay S, Sohn J, Edirisinghe P, Chandrasena R, Wang Z, et al.
Mol Pharmacol
. 2008 Aug;
74(5):1381-91.
PMID: 18676677
Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown promise in colorectal cancer (CRC), but they are compromised by gastrotoxicity. NO-NSAIDs are hybrid nitrates conjugated to an NSAID designed to exploit the gastroprotective...
7.
Chandrasena R, Edirisinghe P, Bolton J, Thatcher G
Chem Res Toxicol
. 2008 Jul;
21(7):1324-9.
PMID: 18588320
Estrogen exposure through early menarche, late menopause, and hormone replacement therapy increases the risk factor for hormone-dependent cancers. Although the molecular mechanisms are not completely established, DNA damage by quinone...
8.
Zhou M, Wu C, Akhmetov A, Edirisinghe P, Drummond J, Hanley L
J Am Soc Mass Spectrom
. 2007 Apr;
18(6):1097-108.
PMID: 17449273
Bisphenol A diglycidyl methacrylate (Bis-GMA) was adsorbed onto or covalently bound to a porous silicon oxide surface. Laser desorption 10.5 eV postionization mass spectrometry (LDPI-MS) was previously demonstrated for surface...
9.
Edirisinghe P, Moore J, Skinner-Nemec K, Lindberg C, Giometti C, Veryovkin I, et al.
Anal Chem
. 2007 Jan;
79(2):508-14.
PMID: 17222014
A novel analytical method based on laser desorption postionization mass spectrometry (LDPI-MS) was developed to investigate the competence and sporulation factor-a pentapeptide of amino acid sequence ERGMT-within intact Bacillus subtilis...
10.
Edirisinghe P, Moore J, Calaway W, Veryovkin I, Pellin M, Hanley L
Anal Chem
. 2006 Aug;
78(16):5876-83.
PMID: 16906735
Experiments demonstrate that peptides with ionization potentials (IPs) above 7.87 eV can be single-photon-ionized in the gas phase with a molecular fluorine laser following prior chemical derivatization with one of...