Pramod Sukumaran
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Explore the profile of Pramod Sukumaran including associated specialties, affiliations and a list of published articles.
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Articles
35
Citations
762
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Recent Articles
11.
Chauhan A, Sun Y, Sukumaran P, Quenum Zangbede F, Jondle C, Sharma A, et al.
iScience
. 2018 Oct;
8:85-102.
PMID: 30293012
Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism(s) regulating their functional phenotypes are ill-defined. Here we report that interferon (IFN) γ priming of naive macrophages induces store-mediated...
12.
Tripathi J, Sharma A, Sukumaran P, Sun Y, Mishra B, Singh B, et al.
FASEB J
. 2018 Jun;
:fj201800605.
PMID: 29906250
Neutrophil extracellular trap (NET) formation constitutes an important extracellular antimicrobial function of neutrophils that plays a protective role in bacterial pneumonia. Formation of reactive oxygen species (ROS) such as highly...
13.
Sun Y, Schaar A, Sukumaran P, Dhasarathy A, Singh B
Mol Carcinog
. 2018 Mar;
57(6):752-761.
PMID: 29500887
Growth factors, such as the transforming growth factor beta (TGFβ), play an important role in promoting metastasis of prostate cancer, thus understanding how TGFβ could induce prostate cancer cell migration...
14.
Sukumaran P, Sun Y, Antonson N, Singh B
FASEB J
. 2017 Nov;
32(3):1640-1652.
PMID: 29150520
Alterations in Ca homeostasis affect neuronal survival. However, the identity of Ca channels and the mechanisms underlying neurotoxin-induced neuronal degeneration are not well understood. In this study, the dopaminergic neurotoxins...
15.
Krout D, Schaar A, Sun Y, Sukumaran P, Roemmich J, Singh B, et al.
J Biol Chem
. 2017 Oct;
292(50):20799-20807.
PMID: 29074621
The transient receptor potential canonical channel-1 (TRPC1) is a Ca-permeable channel found in key metabolic organs and tissues, including the hypothalamus, adipose tissue, and skeletal muscle. Loss of TRPC1 may...
16.
Sukumaran P, Sun Y, Schaar A, Selvaraj S, Singh B
Adv Exp Med Biol
. 2017 May;
976:85-94.
PMID: 28508315
Parkinson's disease (PD) is a common neurodegenerative disorder, which involves degeneration of dopaminergic neurons that are present in the substantia nigra pars compacta (SNpc) region. Many factors have been identified...
17.
Sun Y, Zhang H, Selvaraj S, Sukumaran P, Lei S, Birnbaumer L, et al.
J Neurosci
. 2017 Mar;
37(12):3364-3377.
PMID: 28258168
Loss of dopaminergic (DA) neurons leads to Parkinson's disease; however, the mechanism(s) for the vulnerability of DA neurons is(are) not fully understood. We demonstrate that TRPC1 regulates the L-type Ca...
18.
Sun Y, Sukumaran P, Selvaraj S, Cilz N, Schaar A, Lei S, et al.
Mol Neurobiol
. 2016 Dec;
55(1):409-420.
PMID: 27957685
In neurons, Ca is essential for a variety of physiological processes that regulate gene transcription to neuronal growth and their survival. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium ions (MPP) are potent neurotoxins...
19.
Schaar A, Sukumaran P, Sun Y, Dhasarathy A, Singh B
Oncotarget
. 2016 Oct;
7(49):80554-80567.
PMID: 27793015
Activation of Epithelial-to-Mesenchymal Transition (EMT) is important for tumor metastasis. Although growth factors such as TGFβ and EGF have been shown to induce EMT in breast epithelial cells, the mechanism...
20.
Sukumaran P, Schaar A, Sun Y, Singh B
Cell Calcium
. 2016 Mar;
60(2):123-32.
PMID: 26995055
Intracellular calcium (Ca(2+)) levels play a vital role in regulating cellular fate. The coordination and interrelation among the cellular organelles, mainly the intracellular Ca(2+) stores in endoplasmic reticulum (ER), are...