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Prakash Raman

Explore the profile of Prakash Raman including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 92
Followers 0
Related Specialties
Biochemistry
Pharmacology
Chemistry
Top 10 Co-Authors
Ursula Bodendorf
Richard A Colvin
Brigitte Wiedmann
Jeffery W Kelly
Kiran Dole
Catherine L Jones
Marion Kamke
Craig Smith
Allan DArcy
Jorg Eder
Published In
Bioorg Med Chem Lett
J Org Chem
Proc Natl Acad Sci U S A
J Med Chem
ACS Infect Dis
Affiliations
Soon will be listed here.
Recent Articles
1.
The Safety and Antiviral Activity of BZF961 with or without Ritonavir in Patients Infected with Hepatitis C Virus: A Randomized, Multicenter Trial
Lawitz E, Bidair M, Marbury T, Jones C, Barve A, Magnusson B, et al.
Clin Ther . 2018 Sep; 40(9):1567-1581.e4. PMID: 30185394
Purpose: Infection with hepatitis C virus is the leading cause of infectious disease mortality in the United States. BZF961 is a novel small molecule inhibitor of the hepatitis C virus...
2.
A Diacylglycerol Transferase 1 Inhibitor Is a Potent Hepatitis C Antiviral in Vitro but Not in Patients in a Randomized Clinical Trial
Gane E, Stedman C, Dole K, Chen J, Meyers C, Wiedmann B, et al.
ACS Infect Dis . 2016 Oct; 3(2):144-151. PMID: 27788579
Hepatitis C virus (HCV) infection is a significant cause of liver disease affecting 80-150 million people globally. Diacylglycerol transferase 1 (DGAT-1), a triglyceride synthesis enzyme, is important for the HCV...
3.
2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication
Keaney E, Connolly M, Dobler M, Karki R, Honda A, Sokup S, et al.
Bioorg Med Chem Lett . 2014 Jul; 24(16):3714-8. PMID: 25065492
Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4-kinase beta (PI4KIIIβ) inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIβ leads to potent inhibition of HCV replication as observed...
4.
A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target
Schiering N, DArcy A, Villard F, Simic O, Kamke M, Monnet G, et al.
Proc Natl Acad Sci U S A . 2011 Dec; 108(52):21052-6. PMID: 22160684
Hepatitis C virus (HCV) infection is a global health burden with over 170 million people infected worldwide. In a significant portion of patients chronic hepatitis C infection leads to serious...
5.
Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4
Blackburn C, Guan B, Brown J, Cullis C, Condon S, Jenkins T, et al.
Bioorg Med Chem Lett . 2006 Apr; 16(13):3504-9. PMID: 16644217
Several potent, cell permeable 4-aryl-dihydropyrimidinones have been identified as inhibitors of FATP4. Lipophilic ester substituents at the 5-position and substitution at the para-position (optimal groups being -NO(2) and CF(3)) of...
6.
Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors
Oza V, Smith C, Raman P, Koepf E, Lashuel H, Petrassi H, et al.
J Med Chem . 2002 Jan; 45(2):321-32. PMID: 11784137
Twelve analogues of diclofenac (1), a nonsteroidal antiinflammatory drug and known inhibitor of transthyretin (TTR) amyloid formation, were prepared and evaluated as TTR amyloid formation inhibitors. High activity was exhibited...
7.
Methods to Circumvent a Difficult Coupling in the Solid-Phase Synthesis of Cyclosporine Analogues
Raman P, Stokes S, Angell Y, Flentke G, Rich D
J Org Chem . 2001 Oct; 63(17):5734-5735. PMID: 11672164
No abstract available.