Pragya Goel
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Explore the profile of Pragya Goel including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
616
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Recent Articles
1.
Han Y, Goel P, Chen J, Perry S, Tran N, Nishimura S, et al.
Cell Rep
. 2023 Jul;
42(7):112775.
PMID: 37436892
Ionotropic glutamate receptors (GluRs) are targets for modulation in Hebbian and homeostatic synaptic plasticity and are remodeled by development, experience, and disease. We have probed the impact of synaptic glutamate...
2.
Perry S, Han Y, Qiu C, Chien C, Goel P, Nishimura S, et al.
Nat Commun
. 2022 Dec;
13(1):7656.
PMID: 36496500
Presynaptic homeostatic plasticity (PHP) adaptively enhances neurotransmitter release following diminished postsynaptic glutamate receptor (GluR) functionality to maintain synaptic strength. While much is known about PHP expression mechanisms, postsynaptic induction remains...
3.
Han Y, Chien C, Goel P, He K, Pinales C, Buser C, et al.
Elife
. 2022 Aug;
11.
PMID: 35993544
In developing and mature nervous systems, diverse neuronal subtypes innervate common targets to establish, maintain, and modify neural circuit function. A major challenge towards understanding the structural and functional architecture...
4.
Liu C, Goel P, Kaeser P
Nat Rev Neurosci
. 2021 Apr;
22(6):345-358.
PMID: 33837376
Dopamine is a prototypical neuromodulator that controls circuit function through G protein-coupled receptor signalling. Neuromodulators are volume transmitters, with release followed by diffusion for widespread receptor activation on many target...
5.
Ramesh N, Escher M, Mampell M, Bohme M, Gotz T, Goel P, et al.
Curr Biol
. 2021 Mar;
31(8):1711-1725.e5.
PMID: 33651992
As a result of developmental synapse formation, the presynaptic neurotransmitter release machinery becomes accurately matched with postsynaptic neurotransmitter receptors. Trans-synaptic signaling is executed through cell adhesion proteins such as Neurexin::Neuroligin...
6.
Goel P, Dickman D
Cell Mol Life Sci
. 2021 Jan;
78(7):3159-3179.
PMID: 33449150
Homeostatic signaling systems are fundamental forms of biological regulation that maintain stable functionality in a changing environment. In the nervous system, synapses are crucial substrates for homeostatic modulation, serving to...
7.
Kiragasi B, Goel P, Perry S, Han Y, Li X, Dickman D
Proc Natl Acad Sci U S A
. 2020 Sep;
117(41):25830-25839.
PMID: 32973097
Presynaptic glutamate receptors (GluRs) modulate neurotransmitter release and are physiological targets for regulation during various forms of plasticity. Although much is known about the auxiliary subunits associated with postsynaptic GluRs,...
8.
Goel P, Nishimura S, Chetlapalli K, Li X, Chen C, Dickman D
Front Cell Neurosci
. 2020 Jul;
14:196.
PMID: 32676010
Neurons must establish and stabilize connections made with diverse targets, each with distinct demands and functional characteristics. At neuromuscular junctions (NMJs), synaptic strength remains stable in a manipulation that simultaneously...
9.
Perry S, Goel P, Tran N, Pinales C, Buser C, Miller D, et al.
Development
. 2020 Apr;
147(10).
PMID: 32345746
Synapses exhibit an astonishing degree of adaptive plasticity in healthy and disease states. We have investigated whether synapses also adjust to life stages imposed by novel developmental programs for which...
10.
Kikuma K, Li X, Perry S, Li Q, Goel P, Chen C, et al.
Nat Commun
. 2019 Jul;
10(1):2998.
PMID: 31278365
At the Drosophila neuromuscular junction, inhibition of postsynaptic glutamate receptors activates retrograde signaling that precisely increases presynaptic neurotransmitter release to restore baseline synaptic strength. However, the nature of the underlying...