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Podchanart Wanitchakool

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Articles 26
Citations 873
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Recent Articles
1.
Cabrita I, Benedetto R, Wanitchakool P, Lerias J, Centeio R, Ousingsawat J, et al.
Am J Respir Cell Mol Biol . 2020 Oct; 64(1):50-58. PMID: 33026825
TMEM16A is a Ca-activated chloride channel that was shown to enhance production and secretion of mucus in inflamed airways. It is, however, not clear whether TMEM16A directly supports mucus production,...
2.
Kunzelmann K, Centeio R, Wanitchakool P, Cabrita I, Benedetto R, Saha T, et al.
Front Physiol . 2019 Nov; 10:1262. PMID: 31680994
Cl secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca activated Cl channel Tmem16a was shown to contribute to...
3.
Benedetto R, Ousingsawat J, Cabrita I, Pinto M, Lerias J, Wanitchakool P, et al.
J Mol Med (Berl) . 2019 Mar; 97(5):711-722. PMID: 30915480
The cystic fibrosis transmembrane conductance regulator (CFTR) is the secretory chloride channel in epithelial tissues that has a central role in cystic fibrosis (CF) lung and gastrointestinal disease. A recent...
4.
Ousingsawat J, Wanitchakool P, Schreiber R, Kunzelmann K
Cell Death Dis . 2018 Feb; 9(3):300. PMID: 29463790
Pyroptosis is a highly inflammatory form of programmed cell death that is caused by infection with intracellular pathogens and activation of canonical or noncanonical inflammasomes. The purinergic receptor P2X is...
5.
Lerias J, Pinto M, Botelho H, Awatade N, Quaresma M, Silva I, et al.
Biochim Biophys Acta Mol Cell Res . 2017 Nov; 1865(2):421-431. PMID: 29154949
An attractive possibility to treat Cystic Fibrosis (CF), a severe condition caused by dysfunctional CFTR, an epithelial anion channel, is through the activation of alternative (non-CFTR) anion channels. Anoctamin 1...
6.
Schreiber R, Ousingsawat J, Wanitchakool P, Sirianant L, Benedetto R, Reiss K, et al.
J Physiol . 2017 Nov; 596(2):217-229. PMID: 29134661
Key Points: TMEM16 proteins can operate as Ca -activated Cl channels or scramble membrane phospholipids, which are both highly relevant mechanisms during disease. Overexpression of TMEM16A and TMEM16F were found...
7.
Benedetto R, Ousingsawat J, Wanitchakool P, Zhang Y, Holtzman M, Amaral M, et al.
Sci Rep . 2017 Oct; 7(1):12397. PMID: 28963502
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the secretory chloride/bicarbonate channel in airways and intestine that is activated through ATP binding and phosphorylation by protein kinase A, but fails to...
8.
Simoes F, Ousingsawat J, Wanitchakool P, Fonseca A, Cabrita I, Benedetto R, et al.
Pflugers Arch . 2017 Sep; 470(2):305-314. PMID: 28875346
Cystic fibrosis transmembrane conductance regulator (CFTR) is the essential chloride and bicarbonate channel in the apical membrane of epithelial cells. CFTR was also proposed earlier to conduct glutathione (GSH) out...
9.
Cabrita I, Benedetto R, Fonseca A, Wanitchakool P, Sirianant L, Skryabin B, et al.
FASEB J . 2017 Feb; 31(5):2123-2134. PMID: 28183802
The Ca-activated Cl channel TMEM16A [anoctamin (ANO)1] is homologous to yeast Ist2 and has been shown to tether the cortical endoplasmic reticulum (ER) to the plasma membrane. We therefore examined...
10.
Wanitchakool P, Ousingsawat J, Sirianant L, Cabrita I, Faria D, Schreiber R, et al.
Cell Signal . 2016 Nov; 30:41-49. PMID: 27838374
TMEM16K (ANO10) belongs to a family of ion channels and phospholipid scramblases. Mutations in ANO10 cause neurological and immunological defects, and abrogated ion transport. Here we show that Ano10 knockout...