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Po-Shiuan Hsieh

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Articles 66
Citations 677
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Recent Articles
1.
Huang C, Han I, Hsieh P, Tsai M, Chien H
Basic Clin Pharmacol Toxicol . 2024 Nov; 136(1):e14102. PMID: 39501987
Obesity-induced impairment of myogenic differentiation leads to muscle loss and sarcopenia. Pyruvate dehydrogenase (PDH) plays a crucial role in glucose metabolism and is associated with muscle differentiation. However, the effect...
2.
Tai C, Jian M, Lin T, Chung H, Chang C, Perng C, et al.
Diagnostics (Basel) . 2024 Oct; 14(19). PMID: 39410604
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for rapid and accurate diagnostic tools for upper respiratory tract infections (URTIs). Nucleic acid amplification tests (NAATs) have transformed...
3.
Yang J, Han I, Chen T, Hsieh P, Tsai M, Chien H
Eur J Pharmacol . 2024 Jul; 979:176854. PMID: 39059568
Obesity-induced muscle atrophy leads to physical impairment and metabolic dysfunction, which are risky for older adults. The activity of pyruvate dehydrogenase (PDH), a critical regulator of glucose metabolism, is reduced...
4.
Chen S, Chien H, Tsai S, Jheng Y, Chen Y, Hsieh P, et al.
J Pineal Res . 2024 Jul; 76(5):e12988. PMID: 38982751
Vulnerable atherosclerotic plaque rupture, the leading cause of fatal atherothrombotic events, is associated with an increased risk of mortality worldwide. Peroxisome proliferator-activated receptor delta (PPARδ) has been shown to modulate...
5.
Shih P, Mao Y, Hu J, Hsieh H, Shih T, Lu L, et al.
ACS Pharmacol Transl Sci . 2023 Aug; 5(6):400-412. PMID: 37582235
The rampageous transmission of SARS-CoV-2 has been devastatingly impacting human life and public health since late 2019. The waves of pandemic events caused by distinct coronaviruses at present and over...
6.
Chen C, Chen L, Chung Y, Liu S, Chen S, Chang Y, et al.
Inflammation . 2023 Jul; 46(6):2089-2101. PMID: 37436644
Cysteine-cysteine chemokine receptor type 5 (CCR5) is thought to play an important role in the trafficking of lymphoid cells but has recently also been associated with AMPK signaling pathways that...
7.
Lien C, Lin C, Shyue S, Hsieh P, Chen S, Lin Y, et al.
Br J Pharmacol . 2023 Mar; 180(16):2085-2101. PMID: 36942453
Background And Purpose: Vascular smooth muscle cells (SMCs) undergo phenotypic switching during sustained inflammation, contributing to an unfavourable atherosclerotic plaque phenotype. PPARδ plays an important role in regulating SMC functions;...
8.
Tzeng N, Yang Y, Lin C, Hsieh P, Liu Y
J Integr Neurosci . 2023 Feb; 22(1):12. PMID: 36722248
Background: Second-generation antipsychotics (SGAs) is thought responsible for the metabolic abnormalities of schizophrenic patients, however, some untreated schizophrenic patients had already developed problems with glucose metabolism. The present study examined...
9.
Chen Y, Chang Y, Pathak N, Tzou S, Luo Y, Hsu Y, et al.
Front Immunol . 2023 Jan; 13:1080897. PMID: 36618412
Background: Drug repurposing is a fast and effective way to develop drugs for an emerging disease such as COVID-19. The main challenges of effective drug repurposing are the discoveries of...
10.
Chan P, Lu C, Chien H, Tian Y, Hsieh P
Int J Mol Sci . 2022 Nov; 23(22). PMID: 36430701
The C-C chemokine motif ligand 5 (CCL5) and its receptors have recently been thought to be substantially involved in the development of obesity-associated adipose tissue inflammation and insulin resistance. However,...