Pirkka-Pekka Laurila
Overview
Explore the profile of Pirkka-Pekka Laurila including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
23
Citations
464
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Wohlwend M, Laurila P, Goeminne L, de Lima T, Daskalaki I, Li X, et al.
Elife
. 2024 May;
13.
PMID: 38767943
No abstract available.
2.
Wohlwend M, Laurila P, Goeminne L, Lima T, Daskalaki I, Li X, et al.
Elife
. 2024 Mar;
12.
PMID: 38506902
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis...
3.
Vidal J, Fernandez E, Wohlwend M, Laurila P, Lopez-Mejia A, Ochala J, et al.
J Cachexia Sarcopenia Muscle
. 2023 Nov;
14(6):2882-2897.
PMID: 37964752
Background: Decreased ryanodine receptor type 1 (RyR1) protein levels are a well-described feature of recessive RYR1-related myopathies. The aim of the present study was twofold: (1) to determine whether RyR1...
4.
Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging
Lima T, Laurila P, Wohlwend M, Morel J, Goeminne L, Li H, et al.
Sci Transl Med
. 2023 May;
15(696):eade6509.
PMID: 37196064
Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we...
5.
Laurila P, Wohlwend M, de Lima T, Luan P, Herzig S, Zanou N, et al.
Nat Aging
. 2023 Apr;
2(12):1159-1175.
PMID: 37118545
Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle...
6.
Benegiamo G, Sleiman M, Wohlwend M, Rodriguez-Lopez S, Goeminne L, Laurila P, et al.
Nat Metab
. 2022 Oct;
4(10):1336-1351.
PMID: 36253618
Mitochondrial respiratory complexes form superassembled structures called supercomplexes. COX7A2L is a supercomplex-specific assembly factor in mammals, although its implication for supercomplex formation and cellular metabolism remains controversial. Here we identify...
7.
Laurila P, Luan P, Wohlwend M, Zanou N, Crisol B, de Lima T, et al.
Sci Adv
. 2022 Jan;
8(4):eabh4423.
PMID: 35089797
Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, is a severe muscle disorder, causing muscle weakness, loss of independence, and premature death. Here, we establish the link between sphingolipids...
8.
Wohlwend M, Laurila P, Williams K, Romani M, Lima T, Pattawaran P, et al.
Sci Transl Med
. 2021 Dec;
13(623):eabc7367.
PMID: 34878822
Skeletal muscle displays remarkable plasticity upon exercise and is also one of the organs most affected by aging. Despite robust evidence that aging is associated with loss of fast-twitch (type...
9.
Hoekstra M, Ren B, Laurila P, Hildebrand R, Soronen J, Frodermann V, et al.
Sci Rep
. 2021 Aug;
11(1):16419.
PMID: 34385562
Total body upstream stimulatory factor 1 (USF1) deficiency in mice is associated with brown adipose tissue activation and a marked protection against the development of obesity and atherosclerotic lesions. Functional...
10.
Luan P, DAmico D, Andreux P, Laurila P, Wohlwend M, Li H, et al.
Sci Transl Med
. 2021 Apr;
13(588).
PMID: 33827972
Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD,...