Piotr Bragoszewski
Overview
Explore the profile of Piotr Bragoszewski including associated specialties, affiliations and a list of published articles.
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20
Citations
740
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Recent Articles
1.
Krakowczyk M, Bragoszewski P
Methods Enzymol
. 2024 Nov;
707:173-208.
PMID: 39488374
Mitochondria play multiple essential roles in eukaryotic cells. To perform their functions, mitochondria require an adequate supply of externally produced proteins and an intact two-membrane structure. The structure of mitochondrial...
2.
Krakowczyk M, Lenkiewicz A, Sitarz T, Malinska D, Borrero M, Mussulini B, et al.
J Cell Biol
. 2024 Mar;
223(5.
PMID: 38530280
Most mitochondrial proteins originate from the cytosol and require transport into the organelle. Such precursor proteins must be unfolded to pass through translocation channels in mitochondrial membranes. Misfolding of transported...
3.
Buzzard E, McLaren M, Bragoszewski P, Brancaccio A, Ford H, Daum B, et al.
Biochem J
. 2024 Jan;
PMID: 38164968
Mitochondrial ATP synthases form rows of dimers, which induce membrane curvature to give cristae their characteristic lamellar or tubular morphology. The angle formed between the central stalks of ATP synthase...
4.
Mukhtar M, Thakkur K, Chacinska A, Bragoszewski P
Biochem Soc Trans
. 2023 Nov;
51(6):2117-2126.
PMID: 37987513
Mitochondria are vital to the functions of eukaryotic cells. Most mitochondrial proteins are transported into the organelle following their synthesis by cytoplasmic ribosomes. However, precise protein targeting is complex because...
5.
Lenkiewicz A, Krakowczyk M, Bragoszewski P
Int J Mol Sci
. 2022 Jan;
23(1).
PMID: 35008433
With few exceptions, proteins that constitute the proteome of mitochondria originate outside of this organelle in precursor forms. Such protein precursors follow dedicated transportation paths to reach specific parts of...
6.
Schendzielorz A, Bragoszewski P, Naumenko N, Gomkale R, Schulz C, Guiard B, et al.
Nat Commun
. 2018 Oct;
9(1):4028.
PMID: 30279421
The presequence translocase of the mitochondrial inner membrane (TIM23 complex) facilitates anterograde precursor transport into the matrix and lateral release of precursors with stop-transfer signal into the membrane (sorting). Sorting...
7.
Kowalski L, Bragoszewski P, Khmelinskii A, Glow E, Knop M, Chacinska A
BMC Biol
. 2018 Jun;
16(1):66.
PMID: 29929515
Background: The proteome of mitochondria comprises mostly proteins that originate as precursors in the cytosol. Before import into the organelle, such proteins are exposed to cytosolic quality control mechanisms. Multiple...
8.
Gold V, Chroscicki P, Bragoszewski P, Chacinska A
EMBO Rep
. 2017 Aug;
18(10):1786-1800.
PMID: 28827470
We employed electron cryo-tomography to visualize cytosolic ribosomes on the surface of mitochondria. Translation-arrested ribosomes reveal the clustered organization of the TOM complex, corroborating earlier reports of localized translation. Ribosomes...
9.
Bragoszewski P, Turek M, Chacinska A
Open Biol
. 2017 Apr;
7(4).
PMID: 28446709
Mitochondria are pivotal organelles in eukaryotic cells. The complex proteome of mitochondria comprises proteins that are encoded by nuclear and mitochondrial genomes. The biogenesis of mitochondrial proteins requires their transport...
10.
Wrobel L, Topf U, Bragoszewski P, Wiese S, Sztolsztener M, Oeljeklaus S, et al.
Nature
. 2015 Aug;
524(7566):485-8.
PMID: 26245374
Most of the mitochondrial proteome originates from nuclear genes and is transported into the mitochondria after synthesis in the cytosol. Complex machineries which maintain the specificity of protein import and...