Pinglu Zhang
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Explore the profile of Pinglu Zhang including associated specialties, affiliations and a list of published articles.
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17
Citations
134
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Recent Articles
1.
Zhang P, Wei Y, Tian Q, Zou Q, Wang Y
Genome Res
. 2025 Feb;
PMID: 39939176
The release of the first draft of the human pangenome has revolutionized genomic research by enabling access to complex regions like centromeres, composed of extra-long tandem repeats (ETRs). However, a...
2.
Zhou T, Zhang P, Zou Q, Han W
Bioinformatics
. 2024 Nov;
40(12).
PMID: 39607773
Motivation: HAlign is a high-performance multiple sequence alignment software based on the star alignment strategy, which is the preferred choice for rapidly aligning large numbers of sequences. HAlign3, implemented in...
3.
Zhang P, Lin P, Li D, Wang W, Qi X, Li J, et al.
Biomolecules
. 2024 Oct;
14(10).
PMID: 39456200
The identification of drug-target interaction (DTI) is crucial for drug discovery. However, how to reduce the graph neural network's false positives due to its bias and negative transfer in the...
4.
Tian Q, Zhang P, Zhai Y, Wang Y, Zou Q
Genome Biol Evol
. 2024 May;
16(5).
PMID: 38748485
The advent of high-throughput sequencing technologies has not only revolutionized the field of bioinformatics but has also heightened the demand for efficient taxonomic classification. Despite technological advancements, efficiently processing and...
5.
Zhai Y, Chao J, Wang Y, Zhang P, Tang F, Zou Q
PLoS Comput Biol
. 2024 Apr;
20(4):e1011988.
PMID: 38557416
Accurate multiple sequence alignment (MSA) is imperative for the comprehensive analysis of biological sequences. However, a notable challenge arises as no single MSA tool consistently outperforms its counterparts across diverse...
6.
Zhou C, Liang Y, Li Y, Huang M, Luo Z, Yang K, et al.
Org Lett
. 2024 Feb;
26(9):1941-1946.
PMID: 38415590
Chiral spirocyclopropyl β-lactams are common motifs in bioactive compounds and pharmaceuticals. Here we disclose a diastereoselective and enantioselective hydroborylation and hydrosilylation of spirocyclopropenes, via a Cu-catalyzed desymmetrization strategy, for the...
7.
Lin P, Cheng W, Qi X, Zhang P, Xiong J, Li J
Int J Mol Sci
. 2024 Feb;
25(3).
PMID: 38338834
The Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation is prevalent in lung adenocarcinoma (LUAD), driving tumor progression and indicating a poor prognosis. While the FDA-approved AMG510 (Sotorasib) initially demonstrated...
8.
Zhang P, Liu H, Wei Y, Zhai Y, Tian Q, Zou Q
Bioinformatics
. 2024 Jan;
40(1).
PMID: 38200554
Motivation: In bioinformatics, multiple sequence alignment (MSA) is a crucial task. However, conventional methods often struggle with aligning ultralong sequences. To address this issue, researchers have designed MSA methods rooted...
9.
Zhou C, Huang M, Yao Y, Chen C, Yi X, Yang K, et al.
Org Biomol Chem
. 2023 Nov;
21(48):9534-9541.
PMID: 38009332
Hydroarylation of alkenes is one of the most straightforward and atom-economical strategy for the construction of multi-aryl-substituted alkanes, but systematic studies have been limited to transition metal catalysis. Here we...
10.
Huang M, Zhou C, Yang K, Li Z, Lai G, Zhang P
J Org Chem
. 2023 Sep;
88(19):13838-13846.
PMID: 37750715
An effective (NHC)AgCl catalysis was developed in the hydroborylation of cyclopropenes with Bpin, delivering a variety of cyclopylboronates in a stereoselective manner, which could be easily transformed for the construction...