Ping Tsui
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Explore the profile of Ping Tsui including associated specialties, affiliations and a list of published articles.
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25
Citations
453
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Recent Articles
11.
Shan L, Colazet M, Rosenthal K, Yu X, Bee J, Ferguson A, et al.
PLoS One
. 2016 Aug;
11(8):e0160345.
PMID: 27479095
The immunoglobulin Fc region is a homodimer consisted of two sets of CH2 and CH3 domains and has been exploited to generate two-arm protein fusions with high expression yields, simplified...
12.
Xiao Z, Carrasco R, Schifferli K, Kinneer K, Tammali R, Chen H, et al.
Mol Cancer Ther
. 2016 Feb;
15(4):689-701.
PMID: 26880266
HER3/ERBB3 is a kinase-deficient member of the EGFR family receptor tyrosine kinases (RTK) that is broadly expressed and activated in human cancers. HER3 is a compelling cancer target due to...
13.
Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray L, et al.
J Immunol
. 2015 Jun;
195(3):1182-90.
PMID: 26109638
Small airway chronic inflammation is a major pathologic feature of chronic obstructive pulmonary disease (COPD) and is refractory to current treatments. Dendritic cells (DCs) accumulate around small airways in COPD....
14.
Jack Borrok M, Luheshi N, Beyaz N, Davies G, Legg J, Wu H, et al.
MAbs
. 2015 May;
7(4):743-51.
PMID: 25970007
Fc effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP) are crucial to the efficacy of many antibody therapeutics. In addition to IgG, antibodies of the...
15.
Jack Borrok M, Wu Y, Beyaz N, Yu X, Oganesyan V, DallAcqua W, et al.
J Biol Chem
. 2014 Dec;
290(7):4282-90.
PMID: 25538249
The Fc domain of IgG has been the target of multiple mutational studies aimed at altering the pH-dependent IgG/FcRn interaction to modulate IgG pharmacokinetics. These studies have yielded antibody variants...
16.
Minagawa S, Lou J, Seed R, Cormier A, Wu S, Cheng Y, et al.
Sci Transl Med
. 2014 Jun;
6(241):241ra79.
PMID: 24944194
Airway remodeling, caused by inflammation and fibrosis, is a major component of chronic obstructive pulmonary disease (COPD) and currently has no effective treatment. Transforming growth factor-β (TGF-β) has been widely...
17.
Wilkinson I, Fowler S, Machiesky L, Miller K, Hayes D, Adib M, et al.
MAbs
. 2013 Apr;
5(3):406-17.
PMID: 23567207
Antibodies have become the fastest growing class of biological therapeutics, in part due to their exquisite specificity and ability to modulate protein-protein interactions with a high biological potency. The relatively...
18.
Tornetta M, Baker S, Whitaker B, Lu J, Chen Q, Pisors E, et al.
J Immunol Methods
. 2010 Jul;
360(1-2):39-46.
PMID: 20600082
Fab antibody display on filamentous phage is widely applied to de novo antibody discovery and engineering. Here we describe a phagemid system for the efficient display and affinity selection of...
19.
Shi L, Wheeler J, Sweet R, Lu J, Luo J, Tornetta M, et al.
J Mol Biol
. 2010 Feb;
397(2):385-96.
PMID: 20114051
Filamentous phage was the first display platform employed to isolate antibodies in vitro and is still the most broadly used. The success of phage display is due to its robustness,...
20.
Murray L, Argentieri R, Farrell F, Bracht M, Sheng H, Whitaker B, et al.
Int J Biochem Cell Biol
. 2008 Apr;
40(10):2174-82.
PMID: 18395486
One of the hallmarks of idiopathic pulmonary fibrosis with a usual interstitial pneumonia histological pathology (IPF/UIP) is excess collagen deposition, due to enhanced fibroblast extracellular matrix synthetic activity. Studies using...