Ping-Chang Kuo
Overview
Explore the profile of Ping-Chang Kuo including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
404
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Recent Articles
1.
Kuo P, Zhao Z, Scofield B, Paraiso H, Yu I, Brown D, et al.
J Neuroimmunol
. 2025 Feb;
401:578557.
PMID: 39983262
Multiple sclerosis (MS) is an autoimmune disorder and characterized by immune-mediated neuroinflammation and demyelination triggered by the CNS resident immune cells, microglia (MG), and CNS infiltrating pathogenic T cells. Experimental...
2.
Kuo P, Weng W, Scofield B, Paraiso H, Yu I, Yen J
Front Immunol
. 2024 Oct;
15:1440592.
PMID: 39469715
Cerebral ischemic stroke accounts for more than 80% of all stroke cases. During cerebral ischemia, reactive oxygen species produced in the ischemic brain induce oxidative stress and inflammatory responses. Nrf2...
3.
Kuo P, Weng W, Scofield B, Paraiso H, Bojrab P, Kimes B, et al.
Front Immunol
. 2023 Apr;
14:1148069.
PMID: 37063896
Tissue plasminogen activator (tPA) is the only FDA-approved drug for the treatment of ischemic stroke. Delayed tPA administration is associated with increased risks of blood-brain barrier (BBB) disruption and hemorrhagic...
4.
Weng W, Kuo P, Scofield B, Paraiso H, Brown D, Yu I, et al.
Front Immunol
. 2022 Jul;
13:887000.
PMID: 35860274
Ischemic stroke is caused by a sudden reduction in cerebral blood flow that subsequently induces a complex cascade of pathophysiological responses, leading to brain inflammation and irreversible infarction. 4-ethylguaiacol (4-EG)...
5.
Kuo P, Weng W, Scofield B, Furnas D, Paraiso H, Yu I, et al.
Brain Commun
. 2021 Sep;
3(3):fcab187.
PMID: 34557667
Inflammatory stimuli induce immunoresponsive gene 1 expression that in turn catalyses the production of itaconate through diverting -aconitate away from the tricarboxylic acid cycle. The immunoregulatory effect of the immunoresponsive...
6.
Weng W, Kuo P, Brown D, Scofield B, Furnas D, Paraiso H, et al.
J Neuroinflammation
. 2021 May;
18(1):110.
PMID: 33975618
Background: Multiple sclerosis (MS) is a progressive autoimmune disease characterized by the accumulation of pathogenic inflammatory immune cells in the central nervous system (CNS) that subsequently causes focal inflammation, demyelination,...
7.
Kuo P, Weng W, Scofield B, Furnas D, Paraiso H, Intriago A, et al.
Blood Adv
. 2020 Sep;
4(18):4366-4381.
PMID: 32926126
Tissue plasminogen activator (tPA) is the only US Food and Drug Administration (FDA)-approved drug for ischemic stroke. However, delayed tPA administration is associated with increased risk of blood-brain barrier (BBB)...
8.
Kuo P, Weng W, Scofield B, Paraiso H, Brown D, Wang P, et al.
J Neuroinflammation
. 2020 May;
17(1):138.
PMID: 32349768
Background: Inflammatory stimuli induce immunoresponsive gene 1 (IRG1) expression that in turn catalyzes the production of itaconate from the tricarboxylic acid cycle. Itaconate has recently emerged as a regulator of...
9.
Paraiso H, Wang X, Kuo P, Furnas D, Scofield B, Chang F, et al.
Front Cell Neurosci
. 2020 Apr;
14:84.
PMID: 32327974
Brain microvasculature forms a specialized structure, the blood-brain barrier (BBB), to maintain homeostasis and integrity of the central nervous system (CNS). The BBB dysfunction is emerging as a critical contributor...
10.
Gabet B, Kuo P, Fuentes S, Patel Y, Adow A, Alsakka M, et al.
Bioorg Med Chem
. 2018 Nov;
26(21):5711-5717.
PMID: 30449427
A series of simplified berberine analogs was designed, synthesized, and evaluated for anti-inflammatory activity. SAR studies identified N-benzyltetrahydroisoquinoline 7d as a potent berberine analog. 7d suppressed LPS-induced inflammatory cytokine levels...