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Pierre Martinez

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Articles 31
Citations 5244
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Recent Articles
1.
Beddok A, Velleuer E, Sicre de Fontbrune F, Brakenhoff R, Dalle J, Dufour C, et al.
Cancer Lett . 2025 Mar; 617:217529. PMID: 40054658
Fanconi Anemia (FA) is an inherited disorder associated with profound DNA repair defects, marked by failure to thrive, congenital malformations, progressive bone marrow failure (BMF), and an increased susceptibility to...
2.
Muller L, Fauvet F, Chassot C, Angileri F, Coutant A, Degletagne C, et al.
Cancer Cell Int . 2025 Feb; 25(1):32. PMID: 39901189
Cellular plasticity enables cancer cells to adapt non-genetically, thereby preventing therapeutic success. The epithelial-mesenchymal transition (EMT) is a type of plasticity linked to resistance and metastasis. However, its exact impact...
3.
Coutant A, Cockenpot V, Muller L, Degletagne C, Pommier R, Tonon L, et al.
Lab Invest . 2023 Oct; 103(12):100258. PMID: 37813278
Breast cancer is one of the most prominent types of cancers, in which therapeutic resistance is a major clinical concern. Specific subtypes, such as claudin-low and metaplastic breast carcinoma (MpBC),...
4.
Bouaoud J, Bossi P, Elkabets M, Schmitz S, van Kempen L, Martinez P, et al.
Cancers (Basel) . 2022 Apr; 14(7). PMID: 35406587
Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular...
5.
Gatenbee C, Baker A, Schenck R, Strobl M, West J, Neves M, et al.
Nat Commun . 2022 Apr; 13(1):1798. PMID: 35379804
The evolutionary dynamics of tumor initiation remain undetermined, and the interplay between neoplastic cells and the immune system is hypothesized to be critical in transformation. Colorectal cancer (CRC) presents a...
6.
Truchard E, Bertolus C, Martinez P, Thomas E, Saintigny P, Foy J
Cancers (Basel) . 2022 Feb; 14(3). PMID: 35159101
Background: Our goal was to identify a gene-expression-based surrogate of genomic instability (GI) associated with the transformation of oral potentially malignant disorder (OPMD) into oral squamous cell carcinoma (OSCC). Methods:...
7.
Pommier R, Sanlaville A, Tonon L, Kielbassa J, Thomas E, Ferrari A, et al.
Nat Commun . 2020 Jul; 11(1):3431. PMID: 32647202
Claudin-low breast cancers are aggressive tumors defined by the low expression of key components of cellular junctions, associated with mesenchymal and stemness features. Although they are generally considered as the...
8.
Monteiro L, Da Silva L, Lipinski B, Fauvet F, Vigneron A, Puisieux A, et al.
iScience . 2020 May; 23(5):101061. PMID: 32361272
Despite advances in single-cell and molecular techniques, it is still unclear how to best quantify phenotypic heterogeneity in cancer cells that evolved beyond normal, known classifications. We present an approach...
9.
Roche B, Martinez P
Cancer Inform . 2019 Sep; 18:1176935119872954. PMID: 31523129
The repeatability observed across cancers arising in the same tissue can help understand the evolutionary process of tumour initiation. We recently developed a framework to quantify the local malignant adaptation...
10.
Tokutomi N, Moyret-Lalle C, Puisieux A, Sugano S, Martinez P
Evol Appl . 2019 May; 12(5):1062-1075. PMID: 31080515
Cancer is a potentially lethal disease, in which patients with nearly identical genetic backgrounds can develop a similar pathology through distinct combinations of genetic alterations. We aimed to reconstruct the...