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Pierre Hainaut

Explore the profile of Pierre Hainaut including associated specialties, affiliations and a list of published articles. Areas
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Articles 270
Citations 13565
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Recent Articles
1.
Mevel-Aliset M, Radu A, Allard J, Blanchet S, Montellier E, Hainaut P, et al.
Biochem Biophys Res Commun . 2025 Mar; 755:151571. PMID: 40043609
Lung adenocarcinoma (LUAD) is one of the most prevalent cancer types worldwide and has one of the poorest survival rates. Understanding its developpment is crucial for improving diagnosis, prognosis, and...
2.
Galante P, Guardia G, Pisani J, Sandoval R, Barros-Filho M, Gifoni A, et al.
Lancet Reg Health Am . 2025 Feb; 42:100982. PMID: 39895904
Background: Li-Fraumeni Syndrome (LFS) is a predisposition associated with early onset malignant tumors caused by germline pathogenic variants in the gene. Although rare worldwide, LFS is prevalent in Southern Brazil...
3.
Muntnich L, Dutzmann C, Grosshennig A, Harter V, Keymling M, Mastronuzzi A, et al.
JNCI Cancer Spectr . 2025 Jan; 9(1). PMID: 39873732
Li-Fraumeni syndrome is a cancer predisposition syndrome caused by pathogenic TP53 germline variants; it is associated with a high lifelong cancer risk. We analyzed the German Li-Fraumeni syndrome registry, which...
4.
Montellier E, Lemonnier N, Penkert J, Freycon C, Blanchet S, Amadou A, et al.
iScience . 2024 Dec; 27(12):111296. PMID: 39634561
Li-Fraumeni syndrome (LFS) is a heterogeneous predisposition to an individually variable spectrum of cancers caused by pathogenic germline variants. We used a clustering method to assign TP53 missense variants to...
5.
Freycon C, Palma L, Budd C, Coulombe F, Witkowski L, Hainaut P, et al.
Fam Cancer . 2024 Sep; 23(4):665-669. PMID: 39261343
Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with germline pathogenic/likely pathogenic variants in TP53. Genotype-phenotype correlations are progressively being characterized in LFS with certain TP53 variants associated with...
6.
Casanova A, Roth G, Hausmann S, Lu X, Bischoff L, Froeliger E, et al.
Cell Discov . 2024 Mar; 10(1):34. PMID: 38531836
No abstract available.
7.
Casanova A, Roth G, Hausmann S, Lu X, Bischoff L, Froeliger E, et al.
Cell Discov . 2024 Jan; 10(1):12. PMID: 38296970
Malignant forms of breast cancer refractory to existing therapies remain a major unmet health issue, primarily due to metastatic spread. A better understanding of the mechanisms at play will provide...
8.
Stanfill S, Hecht S, Joerger A, Gonzalez P, Maia L, Rivas M, et al.
Crit Rev Toxicol . 2023 Dec; 53(10):658-701. PMID: 38050998
Tobacco use is a major cause of preventable morbidity and mortality globally. Tobacco products, including smokeless tobacco (ST), generally contain tobacco-specific -nitrosamines (TSNAs), such as '-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone (NNK),...
9.
Levine A, Carpten J, Murphy M, Hainaut P
Cell Death Differ . 2023 Nov; 31(1):1-8. PMID: 38001255
Multiple Myeloma is a typical example of a neoplasm that shows significant differences in incidence, age of onset, type, and frequency of genetic alterations between patients of African and European...
10.
Casanova A, Roth G, Hausmann S, Lu X, Belmudes L, Bourova-Flin E, et al.
bioRxiv . 2023 Oct; PMID: 37790557
Malignant forms of breast cancer refractory to existing therapies remain a major unmet health issue, primarily due to metastatic spread. A better understanding of the mechanisms at play will provide...