Andrea Mencarelli
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Explore the profile of Andrea Mencarelli including associated specialties, affiliations and a list of published articles.
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87
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3308
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Recent Articles
1.
Mencarelli A, Bist P, Choi H, Khameneh H, Mortellaro A, Abraham S
Nat Immunol
. 2024 Mar;
25(4):693-702.
PMID: 38486019
The inflammasome components NLRP3 and ASC are cytosolic proteins, which upon sensing endotoxins or danger cues, form multimeric complexes to process interleukin (IL)-1β for secretion. Here we found that antigen...
2.
Hayes B, Choi H, Rathore A, Bao C, Shi J, Huh Y, et al.
Sci Immunol
. 2024 Mar;
9(93):eadi5578.
PMID: 38427717
Urinary tract infections (UTIs) account for almost 25% of infections in women. Many are recurrent (rUTI), with patients frequently experiencing chronic pelvic pain and urinary frequency despite clearance of bacteriuria...
3.
Mencarelli A, Gunawan M, Yong K, Bist P, Tan W, Tan S, et al.
J Leukoc Biol
. 2020 Jan;
107(5):797-807.
PMID: 31922289
Recently a G-protein-coupled receptor, MAS Related GPR Family Member X2 (MRGPRX2), was identified as a specific receptor on human mast cells responsible for IgE independent adverse drug reactions (ADR). Although...
4.
Khameneh H, Leong K, Mencarelli A, Vacca M, Mambwe B, Neo K, et al.
Front Immunol
. 2019 Aug;
10:1566.
PMID: 31379813
The inflammasome is a multi-protein complex that mediates proteolytic cleavage and release of the pro-inflammatory cytokines IL-1β and IL-18, and pyroptosis-a form of cell death induced by various pathogenic bacteria....
5.
Mencarelli A, Khameneh H, Fric J, Vacca M, El Daker S, Janela B, et al.
Nat Commun
. 2018 Mar;
9(1):1102.
PMID: 29549257
The intestinal immune system can respond to invading pathogens yet maintain immune tolerance to self-antigens and microbiota. Myeloid cells are central to these processes, but the signaling pathways that underlie...
6.
Mencarelli A, Vacca M, Khameneh H, Acerbi E, Tay A, Zolezzi F, et al.
Front Immunol
. 2018 Mar;
9:261.
PMID: 29515579
Calcineurin (Cn) is a protein phosphatase that regulates the activation of the nuclear factor of activated T-cells (NFAT) family of transcription factors, which are key regulators of T-cell development and...
7.
Biagioli M, Mencarelli A, Carino A, Cipriani S, Marchiano S, Fiorucci C, et al.
Inflamm Bowel Dis
. 2017 Dec;
24(1):123-135.
PMID: 29272492
Background: The DNAX adaptor protein 12 (DAP12) is a transmembrane adaptor molecule that signals through the activation of Syk (Spleen Tyrosine Kinase) in myeloid cells. The purpose of this study...
8.
Mencarelli A, Cipriani S, Francisci D, Santucci L, Baldelli F, Distrutti E, et al.
Sci Rep
. 2016 Aug;
6:30802.
PMID: 27492684
Targeted disruption of leukocyte trafficking to the gut represents a promising approach for the treatment of inflammatory bowel diseases (IBDs). CCR5, the shared receptor for MIP1α and β and RANTES,...
9.
Mencarelli A, Graziosi L, Renga B, Cipriani S, DAmore C, Francisci D, et al.
Transl Oncol
. 2014 Jan;
6(6):784-93.
PMID: 24466382
The chemokine (C-C motif) receptor 5 (CCR5) that belongs to the family of G protein-coupled receptors is exploited by macrophage tropic (R5) human immunodeficiency virus type 1 (HIV-1) to enter...
10.
Mencarelli A, DAmore C, Renga B, Cipriani S, Carino A, Sepe V, et al.
Mar Drugs
. 2013 Dec;
12(1):36-53.
PMID: 24368568
In the present study we provide evidence that solomonsterol A, a selective pregnane X receptor (PXR) agonist isolated from the marine sponge Theonella swinhoei, exerts anti-inflammatory activity and attenuates systemic...