Phillipe D OBrien
Overview
Explore the profile of Phillipe D OBrien including associated specialties, affiliations and a list of published articles.
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20
Citations
758
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Recent Articles
1.
Eid S, OBrien P, Kretzler K, Jang D, Mendelson F, Hayes J, et al.
FASEB J
. 2023 Jul;
37(8):e23115.
PMID: 37490006
Patients with type 2 diabetes often develop the microvascular complications of diabetic kidney disease (DKD) and diabetic peripheral neuropathy (DPN), which decrease quality of life and increase mortality. Unfortunately, treatment...
2.
Rumora A, Guo K, Hinder L, OBrien P, Hayes J, Hur J, et al.
Front Physiol
. 2022 Sep;
13:921942.
PMID: 36072849
As the prevalence of prediabetes and type 2 diabetes (T2D) continues to increase worldwide, accompanying complications are also on the rise. The most prevalent complication, peripheral neuropathy (PN), is a...
3.
Gorriz J, Romera I, Cobo A, OBrien P, Merino-Torres J
Diabetes Ther
. 2022 Feb;
13(3):389-421.
PMID: 35175551
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are incretin-mimetic agents that are effective adjuncts in the treatment of diabetes. This class of medications is also associated with promoting weight loss and...
4.
Eid S, OBrien P, Hinder L, Hayes J, Mendelson F, Zhang H, et al.
J Transl Sci
. 2021 Apr;
7(1).
PMID: 33868719
Diabetes is a global healthcare problem associated with enormous healthcare and personal costs. Despite glucose lowering agents that control glycaemia, both type 1 (T1D) and type (T2D) diabetes patients often...
5.
Elzinga S, Savelieff M, OBrien P, Mendelson F, Hayes J, Feldman E
Dis Model Mech
. 2021 Mar;
14(4).
PMID: 33692086
Peripheral neuropathy (PN) is a common complication of prediabetes and diabetes and is an increasing problem worldwide. Existing PN treatments rely solely on glycemic control, which is effective in type...
6.
Eid S, OBrien P, Hinder L, Hayes J, Mendelson F, Zhang H, et al.
Biology (Basel)
. 2020 Oct;
9(11).
PMID: 33105667
Microvascular complications account for the significant morbidity associated with diabetes. Despite tight glycemic control, disease risk remains especially in type 2 diabetes (T2D) patients and no therapy fully prevents nerve,...
7.
OBrien P, Guo K, Eid S, Rumora A, Hinder L, Hayes J, et al.
Dis Model Mech
. 2019 Dec;
13(2).
PMID: 31822493
Peripheral neuropathy (PN) is a complication of prediabetes and type 2 diabetes (T2D). Increasing evidence suggests that factors besides hyperglycaemia contribute to PN development, including dyslipidaemia. The objective of this...
8.
Figueroa-Romero C, Guo K, Murdock B, Paez-Colasante X, Bassis C, Mikhail K, et al.
Dis Model Mech
. 2019 Oct;
13(2).
PMID: 31597644
Amyotrophic lateral sclerosis (ALS) is a terminal neurodegenerative disease. Genetic predisposition, epigenetic changes, aging and accumulated life-long environmental exposures are known ALS risk factors. The complex and dynamic interplay between...
9.
Hinder L, Sas K, OBrien P, Backus C, Kayampilly P, Hayes J, et al.
Sci Rep
. 2019 Jan;
9(1):881.
PMID: 30696927
Diabetic peripheral neuropathy (DPN), diabetic kidney disease (DKD), and diabetic retinopathy (DR) contribute to significant morbidity and mortality in diabetes patients. The incidence of these complications is increasing with the...
10.
OBrien P, Hinder L, Rumora A, Hayes J, Dauch J, Backus C, et al.
Dis Model Mech
. 2018 Nov;
11(12).
PMID: 30446513
Peripheral neuropathy (neuropathy) is a common complication of obesity and type 2 diabetes in children and adolescents. To model this complication in mice, 5-week-old male C57BL/6J mice were fed a...