Phillip A Laycock
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Explore the profile of Phillip A Laycock including associated specialties, affiliations and a list of published articles.
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9
Citations
49
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Recent Articles
1.
Moore K, Li A, Gupta N, Gupta T, Delury C, Aiken S, et al.
Microorganisms
. 2023 Sep;
11(9).
PMID: 37764142
Background: Multispecies biofilm orthopedic infections are more challenging to treat than mono-species infections. In this in-vitro study, we aimed to determine if a multispecies biofilm, consisting of Gram positive and...
2.
Butcher M, Brown J, Hansom D, Wilson-Van Os R, Delury C, Laycock P, et al.
Antimicrob Agents Chemother
. 2021 Oct;
66(1):e0171321.
PMID: 34694875
Candida auris provides a substantial global nosocomial threat clinically. With the recent emergence that the organism can readily colonize skin niches, it will likely continue to pose a risk in...
3.
Brooks J, Dusane D, Moore K, Gupta T, Delury C, Aiken S, et al.
J Bone Jt Infect
. 2021 Jun;
6(5):119-129.
PMID: 34084700
: Bacterial biofilms are an important virulence factor in chronic periprosthetic joint infection (PJI) and other orthopedic infection since they are highly tolerant to antibiotics and host immunity. Antibiotics are...
4.
Moore K, Wilson-Van Os R, Dusane D, Brooks J, Delury C, Aiken S, et al.
Antibiotics (Basel)
. 2021 Apr;
10(3).
PMID: 33800299
Antibiotic-tolerant bacterial biofilms are notorious in causing PJI. Antibiotic loaded calcium sulfate bead (CSB) bone void fillers and PMMA cement and powdered vancomycin (VP) have been used to achieve high...
5.
Butcher M, Brown J, Hansom D, Wilson-Van Os R, Delury C, Laycock P, et al.
Antimicrob Agents Chemother
. 2021 Mar;
65(6).
PMID: 33753336
Calcium sulfate (CS) has been used clinically as a bone- or void-filling biomaterial, and its resorptive properties have provided the prospect for its use as a release mechanism for local...
6.
Jiang N, Dusane D, Brooks J, Delury C, Aiken S, Laycock P, et al.
Sci Rep
. 2021 Jan;
11(1):1446.
PMID: 33446860
This study investigated the efficacy of a biphasic synthetic β-tricalcium phosphate/calcium sulfate (β-TCP/CS) bone graft substitute for compatibility with vancomycin (V) in combination with tobramycin (T) or gentamicin (G) evidenced...
7.
Stoodley P, Brooks J, Peters C, Jiang N, Delury C, Laycock P, et al.
Materials (Basel)
. 2020 Jul;
13(15).
PMID: 32707995
Carbapenem-resistant (CRE) and vancomycin-resistant (VRE) have emerged as multidrug-resistant (MDR) pathogens associated with periprosthetic joint infections (PJI). In this study, we evaluated the efficacy of antibiotic-loaded calcium sulfate beads (ALCSB)...
8.
Dusane D, Brooks J, Sindeldecker D, Peters C, Li A, Farrar N, et al.
Materials (Basel)
. 2019 Dec;
12(24).
PMID: 31817373
(PA) and (SA) are the major causative agents of acute and chronic infections. Antibiotic-loaded calcium sulfate beads (ALCSB) are used in the management of musculoskeletal infections such as periprosthetic joint...
9.
Laycock P, Cooper J, Howlin R, Delury C, Aiken S, Stoodley P
Materials (Basel)
. 2018 Nov;
11(11).
PMID: 30428581
15 different antibiotics were individually mixed with commercially available calcium sulfate bone void filler beads. The antibiotics were: amikacin, ceftriaxone, cefuroxime, ciprofloxacin, clindamycin, colistamethate sodium, daptomycin, gentamicin, imipenem/cilastatin, meropenem, nafcillin,...