Antifungal-Loaded Calcium Sulfate Beads As a Potential Therapeutic in Combating Candida Auris

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2021 Oct 25

PMID 34694875

Authors

Mark C Butcher

Jason L Brown

Donald Hansom

Rebecca Wilson-Van Os

Craig Delury

Phillip A Laycock

Gordon Ramage

Affiliations

Soon will be listed here.

Abstract

Candida auris provides a substantial global nosocomial threat clinically. With the recent emergence that the organism can readily colonize skin niches, it will likely continue to pose a risk in health care units, particularly to patients undergoing surgery. The purpose of this study was to investigate the efficacy of antifungal-loaded calcium sulfate (CS) beads in combatting C. auris infection. We demonstrate that the CS-packed beads have the potential to interfere with planktonic and sessile C. auris.

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