Philipp Saiko
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Explore the profile of Philipp Saiko including associated specialties, affiliations and a list of published articles.
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Articles
54
Citations
667
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Recent Articles
1.
Mahapatra M, Kulandaivelu U, Saiko P, Graser G, Szekeres T, Andrei G, et al.
Chem Zvesti
. 2020 Mar;
67(6):650-656.
PMID: 32214621
Methyl-2-arylidene hydrazine-carbodithioate has not been of particular interest to researchers even though its metal complexes are extensively reported on due to their biological activity. This study examined the cytostatic and...
2.
Ferk F, Kundi M, Brath H, Szekeres T, Al-Serori H, Misik M, et al.
Mol Nutr Food Res
. 2017 Dec;
62(4).
PMID: 29193677
Scope: Oxidative imbalance plays a key role in cancer induction and cardiovascular diseases (CVD) in patients with type 2 diabetes mellitus (T2DM). The aim of this study is to find...
3.
Graser-Loescher G, Schoenhuber A, Ciglenec C, Eberl S, Krupitza G, Mader R, et al.
Food Chem Toxicol
. 2017 Jul;
108(Pt A):53-62.
PMID: 28716444
Cellular growth inhibition exerted by thiosemicarbazones is mainly attributed to down-regulation of ribonucleotide reductase (RNR) activity, with RNR being responsible for the rate-limiting step of de novo DNA synthesis. In...
4.
Nguyen C, Huttary N, Atanasov A, Chatuphonprasert W, Brenner S, Fristiohady A, et al.
Int J Oncol
. 2017 Apr;
50(5):1879-1888.
PMID: 28393180
Lymph node metastasis of breast cancer is a clinical marker of poor prognosis. Yet, there exist no therapies targeting mechanisms of intravasation into lymphatics. Herein we report on an effect...
5.
Nguyen C, Brenner S, Huttary N, Li Y, Atanasov A, Dirsch V, et al.
Cancer Lett
. 2016 Jul;
380(1):174-83.
PMID: 27390016
Secretion of 12(S)-HETE by breast cancer emboli provokes "circular chemorepellent induced defects" (CCIDs) in the adjacent lymphatic vasculature facilitating their intravasation and lymph node metastasis which determines prognosis. Therefore, elucidating...
6.
Molnar J, Szebeni G, Csupor-Loffler B, Hajdu Z, Szekeres T, Saiko P, et al.
Int J Mol Sci
. 2016 Feb;
17(2):83.
PMID: 26901188
Plants and plant extracts play a crucial role in the research into novel antineoplastic agents. Four sesquiterpene lactones, artecanin (1), 3β-chloro-4α,10α-dihydroxy-1α,2α-epoxy-5α,7αH-guaia-11(13)-en-12,6α-olide (2), iso-seco-tanapartholide 3-O-methyl ether (3) and 4β,15-dihydro-3-dehydrozaluzanin C (4),...
7.
Unger C, Kiss I, Vasas A, Lajter I, Kramer N, Atanasov A, et al.
Phytomedicine
. 2015 Jul;
22(9):862-74.
PMID: 26220634
Background: The t(2;5)(p23;q35) chromosomal translocation results in the expression of the fusion protein NPM/ALK that when expressed in T-lymphocytes gives rise to anaplastic large cell lymphomas (ALCL). In search of...
8.
Saiko P, Steinmann M, Schuster H, Graser G, Bressler S, Giessrigl B, et al.
Phytomedicine
. 2015 Feb;
22(1):213-22.
PMID: 25636891
Epigallocatechin gallate (EGCG), ellagic acid (EA) and rosmarinic acid (RA) are natural polyphenols exerting cancer chemopreventive effects. Ribonucleotide reductase (RR; EC 1.17.4.1) converts ribonucleoside diphosphates into deoxyribonucleoside diphosphates being essential...
9.
Kiss I, Unger C, Huu C, Atanasov A, Kramer N, Chatruphonprasert W, et al.
Cancer Lett
. 2014 Dec;
356(2 Pt B):994-1006.
PMID: 25444930
An apolar extract of the traditional medicinal plant Neurolaena lobata inhibited the expression of the NPM/ALK chimera, which is causal for the majority of anaplastic large cell lymphomas (ALCLs). Therefore,...
10.
Teichmann M, Kretschy N, Kopf S, Jarukamjorn K, Atanasov A, Viola K, et al.
Arch Toxicol
. 2013 Dec;
88(3):691-9.
PMID: 24352538
Metastatic breast cancer is linked to an undesired prognosis. One early and crucial metastatic step is the interaction of cancer emboli with adjacent stroma or endothelial cells, and understanding the...