Philipp J Keller
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Explore the profile of Philipp J Keller including associated specialties, affiliations and a list of published articles.
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66
Citations
4603
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Recent Articles
1.
Farrants H, Shuai Y, Lemon W, Monroy Hernandez C, Zhang D, Yang S, et al.
Nat Methods
. 2024 Sep;
21(10):1916-1925.
PMID: 39304767
Genetically encoded fluorescent calcium indicators allow cellular-resolution recording of physiology. However, bright, genetically targetable indicators that can be multiplexed with existing tools in vivo are needed for simultaneous imaging of...
2.
A modular chemigenetic calcium indicator enables in vivo functional imaging with near-infrared light
Farrants H, Shuai Y, Lemon W, Monroy Hernandez C, Yang S, Patel R, et al.
bioRxiv
. 2023 Jul;
PMID: 37503182
Genetically encoded fluorescent calcium indicators have revolutionized neuroscience and other biological fields by allowing cellular-resolution recording of physiology during behavior. However, we currently lack bright, genetically targetable indicators in the...
3.
Malin-Mayor C, Hirsch P, Guignard L, McDole K, Wan Y, Lemon W, et al.
Nat Biotechnol
. 2022 Sep;
41(1):44-49.
PMID: 36065022
We present a method to automatically identify and track nuclei in time-lapse microscopy recordings of entire developing embryos. The method combines deep learning and global optimization. On a mouse dataset,...
4.
Keller J, Marvin J, Lacin H, Lemon W, Shea J, Kim S, et al.
Cell Rep
. 2021 Jun;
35(12):109284.
PMID: 34161775
Glucose is arguably the most important molecule in metabolism, and its dysregulation underlies diabetes. We describe a family of single-wavelength genetically encoded glucose sensors with a high signal-to-noise ratio, fast...
5.
Tyser R, Ibarra-Soria X, McDole K, Jayaram S, Godwin J, van den Brand T, et al.
Science
. 2021 Jan;
371(6533).
PMID: 33414188
The mammalian heart is derived from multiple cell lineages; however, our understanding of when and how the diverse cardiac cell types arise is limited. We mapped the origin of the...
6.
Azizi A, Herrmann A, Wan Y, Buse S, Keller P, Goldstein R, et al.
Elife
. 2020 Oct;
9.
PMID: 33021471
An important question in early neural development is the origin of stochastic nuclear movement between apical and basal surfaces of neuroepithelia during interkinetic nuclear migration. Tracking of nuclear subpopulations has...
7.
Whole-Brain Profiling of Cells and Circuits in Mammals by Tissue Clearing and Light-Sheet Microscopy
Ueda H, Dodt H, Osten P, Economo M, Chandrashekar J, Keller P
Neuron
. 2020 May;
106(3):369-387.
PMID: 32380050
Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields have been combined only recently to facilitate novel experiments and measurements in neuroscience. Since tissue-clearing methods were first...
8.
Ueda H, Erturk A, Chung K, Gradinaru V, Chedotal A, Tomancak P, et al.
Nat Rev Neurosci
. 2020 Mar;
21(5):298.
PMID: 32152524
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
9.
Ueda H, Erturk A, Chung K, Gradinaru V, Chedotal A, Tomancak P, et al.
Nat Rev Neurosci
. 2020 Jan;
21(2):61-79.
PMID: 31896771
State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact tissues from individual organs and even to some entire mammals. When combined with light-sheet microscopy and automated approaches to image analysis,...
10.
Wan Y, Wei Z, Looger L, Koyama M, Druckmann S, Keller P
Cell
. 2019 Oct;
179(2):355-372.e23.
PMID: 31564455
Animal survival requires a functioning nervous system to develop during embryogenesis. Newborn neurons must assemble into circuits producing activity patterns capable of instructing behaviors. Elucidating how this process is coordinated...