Raghav K Chhetri
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Explore the profile of Raghav K Chhetri including associated specialties, affiliations and a list of published articles.
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15
Citations
553
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Recent Articles
1.
Horl D, Rojas Rusak F, Preusser F, Tillberg P, Randel N, Chhetri R, et al.
Nat Methods
. 2019 Aug;
16(9):870-874.
PMID: 31384047
Light-sheet imaging of cleared and expanded samples creates terabyte-sized datasets that consist of many unaligned three-dimensional image tiles, which must be reconstructed before analysis. We developed the BigStitcher software to...
2.
Royer L, Lemon W, Chhetri R, Keller P
Nat Protoc
. 2018 Oct;
13(11):2462-2500.
PMID: 30367170
We describe the implementation and use of an adaptive imaging framework for optimizing spatial resolution and signal strength in a light-sheet microscope. The framework, termed AutoPilot, comprises hardware and software...
3.
Royer L, Lemon W, Chhetri R, Wan Y, Coleman M, Myers E, et al.
Nat Biotechnol
. 2016 Nov;
34(12):1267-1278.
PMID: 27798562
Optimal image quality in light-sheet microscopy requires a perfect overlap between the illuminating light sheet and the focal plane of the detection objective. However, mismatches between the light-sheet and detection...
4.
Chhetri R, Keller P
Elife
. 2016 Sep;
5.
PMID: 27661777
A custom-built objective lens called the Mesolens allows relatively large biological specimens to be imaged with cellular resolution.
5.
Speiser D, Gagnon Y, Chhetri R, Oldenburg A, Johnsen S
Integr Comp Biol
. 2016 Aug;
56(5):796-808.
PMID: 27549200
The eyes of scallops form images using a concave spherical mirror and contain two separate retinas, one layered on top of the other. Behavioral and electrophysiological studies indicate that the...
6.
Chhetri R, Amat F, Wan Y, Hockendorf B, Lemon W, Keller P
Nat Methods
. 2015 Oct;
12(12):1171-8.
PMID: 26501515
Imaging fast cellular dynamics across large specimens requires high resolution in all dimensions, high imaging speeds, good physical coverage and low photo-damage. To meet these requirements, we developed isotropic multiview...
7.
Chhetri R, Blackmon R, Wu W, Hill D, Button B, Casbas-Hernandez P, et al.
Proc Natl Acad Sci U S A
. 2014 Oct;
111(41):E4289-97.
PMID: 25267619
Biological materials exhibit complex nanotopology, i.e., a composite liquid and solid phase structure that is heterogeneous on the nanoscale. The diffusion of nanoparticles in nanotopological environments can elucidate biophysical changes...
8.
Casbas-Hernandez P, DArcy M, Roman-Perez E, Brauer H, McNaughton K, Miller S, et al.
Breast Cancer Res
. 2013 Sep;
15(5):R82.
PMID: 24025166
Introduction: Basal-like and luminal breast cancers have distinct stromal-epithelial interactions, which play a role in progression to invasive cancer. However, little is known about how stromal-epithelial interactions evolve in benign...
9.
Oldenburg A, Chhetri R, Cooper J, Wu W, Troester M, Tracy J
Opt Lett
. 2013 Aug;
38(15):2923-6.
PMID: 23903180
We propose a method for differentiating classes of light scatterers based upon their temporal and polarization properties computed from time series of polarization-sensitive optical coherence tomography (PS-OCT) images. The amplitude...
10.
Chhetri R, Phillips Z, Troester M, Oldenburg A
PLoS One
. 2012 Nov;
7(11):e49148.
PMID: 23152864
The human mammary gland is a complex and heterogeneous organ, where the interactions between mammary epithelial cells (MEC) and stromal fibroblasts are known to regulate normal biology and tumorigenesis. We...