Philip Tsichlis
Overview
Explore the profile of Philip Tsichlis including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
761
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0
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Recent Articles
1.
Sircar A, Singh S, Xu-Monette Z, Coyle K, Hilton L, Chavdoula E, et al.
Leukemia
. 2023 Aug;
37(10):2094-2106.
PMID: 37598282
Mantle cell lymphoma (MCL) is a lethal hematological malignancy with a median survival of 4 years. Its lethality is mainly attributed to a limited understanding of clinical tumor progression and...
2.
Hyde M, Bagley J, Hinds P, Tsichlis P, Iacomini J
Eur J Immunol
. 2021 Aug;
51(11):2576-2589.
PMID: 34363211
Regulatory T cells (Tregs) play a critical role in maintaining self-tolerance and controlling inflammation. However, physiologically relevant conditions that alter Treg function and drive disease pathogenesis are poorly understood and...
3.
Choueiry F, Singh S, Sircar A, Laliotis G, Sun X, Chavdoula E, et al.
Cancers (Basel)
. 2021 May;
13(9).
PMID: 33946867
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL). B-cell NHLs rely on Bruton's tyrosine kinase (BTK) mediated B-cell receptor signaling for survival and disease progression. However,...
4.
Jain N, Singh S, Laliotis G, Hart A, Muhowski E, Kupcova K, et al.
Blood Adv
. 2020 Sep;
4(18):4382-4392.
PMID: 32926124
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma; 40% of patients relapse after a complete response or are refractory to therapy. To survive, the activated...
5.
Sengupta S, Kennemer A, Patrick K, Tsichlis P, Guerau-de-Arellano M
Trends Immunol
. 2020 Sep;
41(10):918-931.
PMID: 32888819
Protein arginine methyltransferase 5 (PRMT5) is the major methyltransferase (MT) catalyzing symmetric dimethylation (SDM). PRMT5 regulates developmental, homeostatic and disease processes in vertebrates and invertebrates, and a carcinogenic role has...
6.
Peterson J, Lin B, Shin J, Phelan P, Tsichlis P, Schwob J, et al.
J Virol
. 2017 Aug;
91(20).
PMID: 28768870
Progressive multifocal leukoencephalopathy (PML) is an often-fatal demyelinating disease of the central nervous system. PML results when oligodendrocytes within immunocompromised individuals are infected with the human JC virus (JCV). We...
7.
McNab F, Ewbank J, Rajsbaum R, Stavropoulos E, Martirosyan A, Redford P, et al.
J Immunol
. 2013 Jul;
191(4):1732-43.
PMID: 23842752
Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading cause of mortality and morbidity worldwide, causing ≈ 1.4 million deaths per year. Key immune components for host protection during tuberculosis include...
8.
Lindner H, Zhang A, Eldridge J, Demcheva M, Tsichlis P, Tsichilis P, et al.
PLoS One
. 2011 May;
6(4):e18996.
PMID: 21559496
Background: Treatment of cutaneous wounds with poly-N-acetyl-glucosamine nanofibers (sNAG) results in increased kinetics of wound closure in diabetic animal models, which is due in part to increased expression of several...
9.
Stankovic S, Gugasyan R, Kyparissoudis K, Grumont R, Banerjee A, Tsichlis P, et al.
Immunol Cell Biol
. 2010 Aug;
89(2):294-303.
PMID: 20697425
The nuclear factor (NF)-κB signalling pathway is known to be critical for natural killer T (NKT) cell differentiation; however, the role of individual NF-κB transcription factors and the precise developmental...
10.
Kontoyiannis D, Boulougouris G, Manoloukos M, Armaka M, Apostolaki M, Pizarro T, et al.
J Exp Med
. 2002 Dec;
196(12):1563-74.
PMID: 12486099
Recent clinical evidence demonstrated the importance of tumor necrosis factor (TNF) in the development of Crohn's disease. A mouse model for this pathology has previously been established by engineering defects...