Philip T LoVerde
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Explore the profile of Philip T LoVerde including associated specialties, affiliations and a list of published articles.
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83
Citations
2115
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Recent Articles
1.
Wu W, LoVerde P
PLoS One
. 2024 Dec;
19(12):e0315840.
PMID: 39666654
[This corrects the article DOI: 10.1371/journal.pone.0250750.].
2.
LoVerde P
Adv Exp Med Biol
. 2024 Jul;
1454:75-105.
PMID: 39008264
Schistosomiasis is a major cause of morbidity in the world and almost 800 million people worldwide are at risk for schistosomiasis; it is second only to malaria as a major...
3.
Wu W, LoVerde P
PLoS One
. 2023 Sep;
18(9):e0286107.
PMID: 37699039
Nuclear receptors (NRs) are important transcriptional modulators in metazoans. Typical NRs possess a conserved DNA binding domain (DBD) and a ligand binding domain (LBD). Since we discovered a type of...
4.
Alwan S, Taylor A, Rhodes J, Tidwell M, McHardy S, LoVerde P
PLoS Pathog
. 2023 Jul;
19(7):e1011018.
PMID: 37428793
Human schistosomiasis is a neglected tropical disease caused by Schistosoma mansoni, S. haematobium, and S. japonicum. Praziquantel (PZQ) is the method of choice for treatment. Due to constant selection pressure,...
5.
Toth K, Alwan S, Khan S, McHardy S, LoVerde P, Cameron M
Int J Parasitol Drugs Drug Resist
. 2023 Feb;
21:65-73.
PMID: 36758271
The antischistosomal drug oxamniquine, OXA, requires activation by a sulfotransferase within the parasitic worm to enable killing. Examination of the pharmacokinetic/pharmacodynamic (PK/PD) relationship for OXA identified an in vitro-in vivo...
6.
Guzman M, Rugel A, Alwan S, Tarpley R, Taylor A, Chevalier F, et al.
Pharmaceutics
. 2022 Jul;
14(7).
PMID: 35890311
Oxamniquine (OXA) is a prodrug activated by a sulfotransferase () that was only active against . We have reengineered OXA to be effective against and . Three derivatives stand out,...
7.
Platt 2nd R, Le Clech W, Chevalier F, McDew-White M, LoVerde P, de Assis R, et al.
Mol Ecol
. 2022 Feb;
31(8):2242-2263.
PMID: 35152493
Schistosoma mansoni, a snail-borne, blood fluke that infects humans, was introduced into the Americas from Africa during the Trans-Atlantic slave trade. As this parasite shows strong specificity to the snail...
8.
LoVerde P, Alwan S, Taylor A, Rhodes J, Chevalier F, Anderson T, et al.
Int J Parasitol Drugs Drug Resist
. 2022 Jan;
18:103.
PMID: 35067439
No abstract available.
9.
Alwan S, LoVerde P
Mol Biochem Parasitol
. 2021 Sep;
245:111412.
PMID: 34492240
During schistosomiasis, the paired Schistosoma mansoni female produces about 300 eggs each day. These eggs are responsible for the clinical picture and the transmission of the disease. During female development...
10.
Wu W, LoVerde P
PLoS One
. 2021 Aug;
16(8):e0250750.
PMID: 34388160
Since the first complete set of Platyhelminth nuclear receptors (NRs) from Schistosoma mansoni were identified a decade ago, more flatworm genome data is available to identify their NR complement and...