Philip T LoVerde
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Explore the profile of Philip T LoVerde including associated specialties, affiliations and a list of published articles.
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83
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2115
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Recent Articles
11.
LoVerde P, Alwan S, Taylor A, Rhodes J, Chevalier F, Anderson T, et al.
Int J Parasitol Drugs Drug Resist
. 2021 Jun;
16:140-147.
PMID: 34111649
Human schistosomiasis is a debilitating, life-threatening disease affecting more than 229 million people in as many as 78 countries. There is only one drug of choice effective against all three...
12.
Guzman M, Rugel A, Tarpley R, Alwan S, Chevalier F, Kovalskyy D, et al.
PLoS Negl Trop Dis
. 2020 Aug;
14(8):e0008517.
PMID: 32810153
Currently there is only one method of treatment for human schistosomiasis, the drug praziquantel. Strong selective pressure has caused a serious concern for a rise in resistance to praziquantel leading...
13.
Rugel A, Guzman M, Taylor A, Chevalier F, Tarpley R, McHardy S, et al.
Int J Parasitol Drugs Drug Resist
. 2020 Apr;
13:8-15.
PMID: 32315953
Human schistosomiasis is a disease which globally affects over 229 million people. Three major species affecting humans are Schistosoma mansoni, S. haematobium and S. japonicum. Previous treatment of S. mansoni...
14.
Guzman M, Rugel A, Tarpley R, Cao X, McHardy S, LoVerde P, et al.
Mol Biochem Parasitol
. 2020 Feb;
236:111257.
PMID: 32027942
Hycanthone (HYC) is a retired drug formerly used to treat schistosomiasis caused by infection from Schistosoma mansoni and S. haematobium. Resistance to HYC was first observed in S. mansoni laboratory...
15.
Chevalier F, Le Clech W, McDew-White M, Menon V, Guzman M, Holloway S, et al.
PLoS Pathog
. 2019 Oct;
15(10):e1007881.
PMID: 31652296
Do mutations required for adaptation occur de novo, or are they segregating within populations as standing genetic variation? This question is key to understanding adaptive change in nature, and has...
16.
Wu W, LoVerde P
Mol Biochem Parasitol
. 2019 Aug;
233:111218.
PMID: 31470045
Nuclear receptors (NRs) belong to a large protein superfamily which includes intracellular receptors for secreted hydrophobic signal molecules, such as steroid hormones and thyroid hormones. They regulate development and reproduction...
17.
LoVerde P
Adv Exp Med Biol
. 2019 Jul;
1154:45-70.
PMID: 31297759
Schistosomiasis is a major cause of morbidity in the world; it is second only to malaria as a major infectious disease. Globally, it is estimated that the disease affects over...
18.
Rugel A, Tarpley R, Lopez A, Menard T, Guzman M, Taylor A, et al.
ACS Med Chem Lett
. 2018 Oct;
9(10):967-973.
PMID: 30344901
Schistosomiasis is a major human parasitic disease afflicting more than 250 million people, historically treated with chemotherapies praziquantel or oxamniquine. Since oxamniquine is species-specific, killing but not other schistosome species...
19.
Anderson T, LoVerde P, Le Clech W, Chevalier F
Trends Parasitol
. 2018 Aug;
34(11):982-996.
PMID: 30150002
Linkage mapping - utilizing experimental genetic crosses to examine cosegregation of phenotypic traits with genetic markers - is now 100 years old. Schistosome parasites are exquisitely well suited to linkage...
20.