Philip S Stewart
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Explore the profile of Philip S Stewart including associated specialties, affiliations and a list of published articles.
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113
Citations
7228
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Recent Articles
11.
Bjarnsholt T, Whiteley M, Rumbaugh K, Stewart P, Jensen P, Frimodt-Moller N
Lancet Infect Dis
. 2021 Sep;
22(3):e88-e92.
PMID: 34506737
Standard doses of antibiotics do not efficiently treat chronic infections of the soft tissue and bone. In this Personal View, we advocate for improving treatment of these infections by taking...
12.
Koenig H, Durling G, Walsh D, Livinghouse T, Stewart P
Antibiotics (Basel)
. 2021 Aug;
10(7).
PMID: 34356776
The synthesis and biological activity of several novel nitrothiazole, nitrobenzothiazole, and nitrofuran containing antimicrobial agents for the eradication of biofilm-forming Gram-negative and Gram-positive pathogens is described. Nitazoxanide (NTZ), nitrofurantoin, and...
13.
Pettygrove B, Kratofil R, Alhede M, Jensen P, Newton M, Qvortrup K, et al.
Biomaterials
. 2021 Jul;
275:120775.
PMID: 34243039
Biofilms that form on implanted medical devices cause recalcitrant infections. The early events enabling contaminating bacteria to evade immune clearance, before a mature biofilm is established, are poorly understood. Live...
14.
Bjarnsholt T, Mastroianni E, Kirketerp-Moller K, Stewart P, Mahr A, Dominguez Cabanes A, et al.
APMIS
. 2021 Jun;
129(10):598-606.
PMID: 34120370
Research on biofilms is predominantly made in in vitro contexts. However, in vivo observation of biofilms in human chronic infections shows distinct differences compared to in vitro biofilm growth. This...
15.
Zea L, McLean R, Rook T, Angle G, Carter D, Delegard A, et al.
Biofilm
. 2021 Jan;
2:100026.
PMID: 33447811
Biofilms, surface-adherent microbial communities, are associated with microbial fouling and corrosion in terrestrial water-distribution systems. Biofilms are also present in human spaceflight, particularly in the Water Recovery System (WRS) on...
16.
Walsh D, Livinghouse T, Durling G, Arnold A, Brasier W, Berry L, et al.
Chem Biol Drug Des
. 2020 Aug;
97(1):134-147.
PMID: 32844569
Prodrugs are pharmacologically attenuated derivatives of drugs that undergo bioconversion into the active compound once reaching the targeted site, thereby maximizing their efficiency. This strategy has been implemented in pharmaceuticals...
17.
The zone model: A conceptual model for understanding the microenvironment of chronic wound infection
Kirketerp-Moller K, Stewart P, Bjarnsholt T
Wound Repair Regen
. 2020 Jun;
28(5):593-599.
PMID: 32529778
In 2008, two articles in Wound Repair and Regeneration changed the clinical perspective on chronic wounds. They stated that chronic wounds that do not heal contain bacterial biofilms and that...
18.
Ferrer-Espada R, Sanchez-Gomez S, Pitts B, Stewart P, Martinez-de-Tejada G
Int J Antimicrob Agents
. 2020 Apr;
56(1):105986.
PMID: 32335279
Objectives: β-lactamases are the major resistance determinant for β-lactam antibiotics in Gram-negative bacteria. Although there are β-lactamase inhibitors (BLIs) available, β-lactam-BLI combinations are increasingly being neutralised by diverse mechanisms of...
19.
Walsh D, Livinghouse T, Durling G, Chase-Bayless Y, Arnold A, Stewart P
ACS Omega
. 2020 Apr;
5(11):6010-6020.
PMID: 32226882
The recalcitrance exhibited by microbial biofilms to conventional disinfectants has motivated the development of new chemical strategies to control and eradicate biofilms. The activities of several small phenolic compounds and...
20.
Simkins J, Stewart P, Codd S, Seymour J
Biotechnol Bioeng
. 2020 Jan;
117(5):1458-1469.
PMID: 31956979
F nuclear magnetic resonance (NMR) oximetry and H NMR velocimetry were used to noninvasively map oxygen concentrations and hydrodynamics in space and time in a model packed bed biofilm system...