Philip P Connell
Overview
Explore the profile of Philip P Connell including associated specialties, affiliations and a list of published articles.
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Articles
39
Citations
1050
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Recent Articles
11.
Chmura S, Connell P, Weichselbaum R
J Natl Cancer Inst
. 2017 Nov;
110(4):325-326.
PMID: 29126281
No abstract available.
12.
Akthar A, Koshy M, Ferguson M, Murgu S, Hogarth D, Golden D, et al.
Clin Lung Cancer
. 2017 Sep;
19(2):e227-e233.
PMID: 28939097
Background: In this study we sought to determine if staging endoscopic bronchial ultrasound (EBUS) improves outcomes in stage I non-small-cell lung cancer (NSCLC) patients who received hypofractionated radiation therapy (HFRT)....
13.
Pitroda S, Bao R, Andrade J, Weichselbaum R, Connell P
Clin Cancer Res
. 2017 Mar;
23(15):4493-4500.
PMID: 28341751
Molecular-based cancer tests have been developed to augment the standard clinical and pathologic features used to tailor treatments to individual breast cancer patients. Homologous recombination (HR) repairs double-stranded DNA breaks...
14.
Budke B, Lv W, Kozikowski A, Connell P
ChemMedChem
. 2016 Oct;
11(22):2468-2473.
PMID: 27781374
Homologous recombination (HR) is an evolutionarily conserved DNA repair process. Overexpression of the key HR protein RAD51 is a common feature of malignant cells. RAD51 plays two distinct genome-stabilizing roles,...
15.
Lv W, Budke B, Pawlowski M, Connell P, Kozikowski A
J Med Chem
. 2016 Apr;
59(10):4511-25.
PMID: 27049177
RAD51 is the central protein in homologous recombination (HR) DNA repair and represents a therapeutic target in oncology. Herein we report a novel class of RAD51 inhibitors that were identified...
16.
Spiotto M, Connell P
Oral Maxillofac Surg Clin North Am
. 2015 Nov;
28(1):115-26.
PMID: 26614704
Most pediatric head and neck cancers are treated with radiotherapy, but the morbidity associated with radiotherapy has become a prominent issue. This article discusses the common long-term complications associated with...
17.
Mason J, Dusad K, Wright W, Grubb J, Budke B, Heyer W, et al.
Nucleic Acids Res
. 2015 Mar;
43(6):3180-96.
PMID: 25765654
The RAD54 family DNA translocases have several biochemical activities. One activity, demonstrated previously for the budding yeast translocases, is ATPase-dependent disruption of RAD51-dsDNA binding. This activity is thought to promote...
18.
Mason J, Logan H, Budke B, Wu M, Pawlowski M, Weichselbaum R, et al.
Cancer Res
. 2014 Apr;
74(13):3546-55.
PMID: 24753542
RAD51 is the central protein that catalyzes DNA repair via homologous recombination, a process that ensures genomic stability. RAD51 protein is commonly expressed at high levels in cancer cells relative...
19.
Pitroda S, Pashtan I, Logan H, Budke B, Darga T, Weichselbaum R, et al.
Sci Transl Med
. 2014 Mar;
6(229):229ra42.
PMID: 24670686
Mutagenesis is a hallmark of malignancy, and many oncologic treatments function by generating additional DNA damage. Therefore, DNA damage repair is centrally important in both carcinogenesis and cancer treatment. Homologous...
20.
Connell P, Weichselbaum R
Proc Natl Acad Sci U S A
. 2013 Nov;
110(46):18355-6.
PMID: 24187150
No abstract available.