Philip P Connell
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Explore the profile of Philip P Connell including associated specialties, affiliations and a list of published articles.
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39
Citations
1050
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Recent Articles
1.
Hammad A, Ahmed O, Connell P, Olson D, Balach T
JBJS Rev
. 2023 Feb;
11(1).
PMID: 36722819
»: Optimal care for pathologic fractures centers on the use of a multidisciplinary team; thus, whenever there is a concern for pathologic fracture and proper workup is unable to be...
2.
Spurr L, Martinez C, Katipally R, Iyer S, Pugh S, Bridgewater J, et al.
NPJ Precis Oncol
. 2022 Oct;
6(1):72.
PMID: 36241710
Personalized treatment approaches for patients with limited liver metastases from colorectal cancer are critically needed. By leveraging three large, independent cohorts of patients with colorectal liver metastases (n = 336),...
3.
Budke B, Zhong A, Sullivan K, Park C, Gittin D, Kountz T, et al.
Nucleic Acids Res
. 2022 Jun;
50(11):6251-6263.
PMID: 35689636
Homologous recombination (HR) serves multiple roles in DNA repair that are essential for maintaining genomic stability, including double-strand DNA break (DSB) repair. The central HR protein, RAD51, is frequently overexpressed...
4.
Xu J, Zhao L, Peng S, Chu H, Liang R, Tian M, et al.
Nucleic Acids Res
. 2021 Dec;
49(22):13135-13149.
PMID: 34871438
Homologous recombination (HR) is a primary DNA double-strand breaks (DSBs) repair mechanism. The recombinases Rad51 and Dmc1 are highly conserved in the RecA family; Rad51 is mainly responsible for DNA...
5.
Zuo K, Yuan X, Liang X, Sun X, Liu S, Connell P, et al.
Breast Cancer Res Treat
. 2021 Nov;
191(2):335-344.
PMID: 34797456
Purpose: Cumulative evidence suggests that the addition of platinum agents as neoadjuvant chemotherapy (NACT) could improve the pathologic complete response (pCR) rate in triple-negative breast cancer (TNBC). We aimed to...
6.
Gutiontov S, Turchan W, Spurr L, Rouhani S, Chervin C, Steinhardt G, et al.
Sci Rep
. 2021 Oct;
11(1):20059.
PMID: 34625620
Immune checkpoint blockade (ICB) improves outcomes in non-small cell lung cancer (NSCLC) though most patients progress. There are limited data regarding molecular predictors of progression. In particular, there is controversy...
7.
Rosenberg D, Onderdonk B, Majeed N, Guzman G, Farid Y, Connell P, et al.
JBJS Case Connect
. 2019 Dec;
9(4):e0146.
PMID: 31815809
Case: Heterotopic ossification (HO) is a pathological formation of bone in nonosseous tissue and is a common complication of orthopaedic procedures. Radiotherapy is often used to prevent HO despite the...
8.
Tatebe K, Chmura S, Connell P
Pract Radiat Oncol
. 2019 Jun;
9(6):492-495.
PMID: 31185301
No abstract available.
9.
Budke B, Tueckmantel W, Miles K, Kozikowski A, Connell P
ChemMedChem
. 2019 Apr;
14(10):1031-1040.
PMID: 30957434
RAD51 is the central protein in homologous recombination (HR) repair, where it first binds ssDNA and then catalyzes strand invasion via a D-loop intermediate. Additionally, RAD51 plays a role in...
10.
Chlenski A, Park C, Dobratic M, Salwen H, Budke B, Park J, et al.
Mol Cancer Ther
. 2019 Jan;
18(3):507-516.
PMID: 30674566
Maternal embryonic leucine zipper kinase (MELK) activates pathways that mediate aggressive tumor growth and therapy resistance in many types of adult cancers. Pharmacologic and genomic inhibition of MELK impairs tumor...