Philip P Ahern
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Explore the profile of Philip P Ahern including associated specialties, affiliations and a list of published articles.
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3663
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Recent Articles
11.
Johnston I, Osborn L, Markley R, McManus E, Kadam A, Schultz K, et al.
NPJ Biofilms Microbiomes
. 2021 Jul;
7(1):56.
PMID: 34215744
Aryl polyenes (APEs) are specialized polyunsaturated carboxylic acids that were identified in silico as the product of the most widespread family of bacterial biosynthetic gene clusters (BGCs). They are present...
12.
Wu M, Chen Y, Xia H, Wang C, Tan C, Cai X, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(45):28336-28343.
PMID: 33082228
Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, has resulted thus far in greater than 933,000 deaths worldwide; yet disease pathogenesis remains unclear. Clinical and immunological features of...
13.
Luccia B, Ahern P, Griffin N, Cheng J, Guruge J, Byrne A, et al.
Cell Host Microbe
. 2020 Apr;
27(6):899-908.e5.
PMID: 32348782
Undernourished children in low-income countries often exhibit poor responses to oral vaccination. Perturbed microbiota development is linked to undernutrition, but whether and how microbiota changes affect vaccine responsiveness remains unclear....
14.
Ahern P, Maloy K
Immunology
. 2019 Nov;
159(1):4-14.
PMID: 31777071
The past two decades have seen an explosion in research that aims to understand how the dynamic interplay with the gut microbiota impacts host health and disease, establishing a role...
15.
Cowardin C, Ahern P, Kung V, Hibberd M, Cheng J, Guruge J, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(24):11988-11996.
PMID: 31138692
Undernutrition in children is a pressing global health problem, manifested in part by impaired linear growth (stunting). Current nutritional interventions have been largely ineffective in overcoming stunting, emphasizing the need...
16.
Cervantes-Barragan L, Chai J, Tianero M, Luccia B, Ahern P, Merriman J, et al.
Science
. 2017 Aug;
357(6353):806-810.
PMID: 28775213
The small intestine contains CD4CD8αα double-positive intraepithelial lymphocytes (DP IELs), which originate from intestinal CD4 T cells through down-regulation of the transcription factor Thpok and have regulatory functions. DP IELs...
17.
Griffin N, Ahern P, Cheng J, Heath A, Ilkayeva O, Newgard C, et al.
Cell Host Microbe
. 2017 Jan;
21(1):84-96.
PMID: 28041931
Ensuring that gut microbiota respond consistently to prescribed dietary interventions, irrespective of prior dietary practices (DPs), is critical for effective nutritional therapy. To address this, we identified DP-associated gut bacterial...
18.
Semenkovich N, Planer J, Ahern P, Griffin N, Lin C, Gordon J
Proc Natl Acad Sci U S A
. 2016 Dec;
113(51):14805-14810.
PMID: 27911843
The gut microbiota impacts many aspects of host biology including immune function. One hypothesis is that microbial communities induce epigenetic changes with accompanying alterations in chromatin accessibility, providing a mechanism...
19.
Wagner V, Dey N, Guruge J, Hsiao A, Ahern P, Semenkovich N, et al.
Sci Transl Med
. 2016 Nov;
8(366):366ra164.
PMID: 27881825
To model how interactions among enteropathogens and gut microbial community members contribute to undernutrition, we colonized gnotobiotic mice fed representative Bangladeshi diets with sequenced bacterial strains cultured from the fecal...
20.
Krausgruber T, Schiering C, Adelmann K, Harrison O, Chomka A, Pearson C, et al.
Nat Commun
. 2016 May;
7:11627.
PMID: 27193261
IL-23 is a key driver of pathogenic Th17 cell responses. It has been suggested that the transcription factor T-bet is required to facilitate IL-23-driven pathogenic effector functions; however, the precise...