Philip N Tsichlis
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Explore the profile of Philip N Tsichlis including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Guerau-de-Arellano M, Piedra-Quintero Z, Tsichlis P
Front Immunol
. 2022 Sep;
13:990874.
PMID: 36081513
Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt's expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune...
12.
Wang Y, Ilyas F, Kheradmandi M, Tsilimigras D, Grignol V, Contreras C, et al.
Mol Cancer Res
. 2022 Jul;
20(10):1471-1480.
PMID: 35796636
Soft tissue sarcomas (STS) are a biologically diverse group of mesenchymal tumors that predominantly exhibit a poor prognosis. Surgical resection is considered the mainstay of treatment and provides the only...
13.
Laliotis G, Chavdoula E, Paraskevopoulou M, Kaba A, La Ferlita A, Singh S, et al.
Nat Commun
. 2022 Jun;
13(1):3711.
PMID: 35764644
No abstract available.
14.
Tsimberidou A, Skliris A, Valentine A, Shaw J, Hering U, Vo H, et al.
Cell Biosci
. 2022 May;
12(1):56.
PMID: 35525984
Background: Changes in the expression and activity of the AKT oncogene play an important role in psychiatric disease. We present translational data assessing the role of AKT in psychiatric symptoms....
15.
Wang W, Shulman A, Amann J, Carbone D, Tsichlis P
Semin Cancer Biol
. 2022 Apr;
86(Pt 2):543-554.
PMID: 35398266
Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor, accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid growth and early metastasis. Despite...
16.
Laliotis G, Kenney A, Chavdoula E, Orlacchio A, Kaba A, La Ferlita A, et al.
Commun Biol
. 2021 Dec;
4(1):1419.
PMID: 34912055
No abstract available.
17.
Sengupta S, West K, Sanghvi S, Laliotis G, Agosto L, Lynch K, et al.
Immunohorizons
. 2021 Oct;
5(10):884-897.
PMID: 34716181
Protein arginine methyltransferase (PRMT) 5 is the type 2 methyltransferase catalyzing symmetric dimethylation of arginine. PRMT5 inhibition or deletion in CD4 Th cells reduces TCR engagement-induced IL-2 production and Th...
18.
Laliotis G, Kenney A, Chavdoula E, Orlacchio A, Kaba A, La Ferlita A, et al.
Commun Biol
. 2021 Oct;
4(1):1179.
PMID: 34635782
AKT-phosphorylated IWS1 promotes Histone H3K36 trimethylation and alternative RNA splicing of target genes, including the U2AF65 splicing factor-encoding U2AF2. The predominant U2AF2 transcript, upon IWS1 phosphorylation block, lacks the RS-domain-encoding...
19.
Saif M, Rajagopal S, Caplain J, Goodman M, Popowich D, Orkin B, et al.
Cancer Med J
. 2021 Aug;
4(Suppl 4):1-10.
PMID: 34368808
Background: The cancer stem cell (CSC) hypothesis of tumor genesis suggests that unlike most cancer cells within tumor CSC resist chemotherapy and can regenerate various cell types in tumor thereby...
20.
Laliotis G, Chavdoula E, Paraskevopoulou M, Kaba A, La Ferlita A, Singh S, et al.
Nat Commun
. 2021 Jul;
12(1):4624.
PMID: 34330897
AKT-phosphorylated IWS1 regulates alternative RNA splicing via a pathway that is active in lung cancer. RNA-seq studies in lung adenocarcinoma cells lacking phosphorylated IWS1, identified a exon 2-deficient U2AF2 splice...