Philip N Tsichlis
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Explore the profile of Philip N Tsichlis including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Nagy G, Presley R, Dhar S, Jeon H, Moreira L, Tull O, et al.
bioRxiv
. 2024 Nov;
PMID: 39605359
Herpes Simplex Virus 1 evades the host immune system by expressing a protein, ICP47, that binds to and inhibits the heterodimeric Transporter Associated with Antigen Processing (TAP). We screened a...
2.
Anastas V, Chavdoula E, La Ferlita A, Soysal B, Cosentini I, Nigita G, et al.
bioRxiv
. 2024 Jun;
PMID: 38826406
KDM2B is a JmjC domain lysine demethylase, which promotes cell immortalization, stem cell self-renewal and tumorigenesis. Here we employed a multi-omics strategy to address its role in ribosome biogenesis and...
3.
La Ferlita A, Alaimo S, Nigita G, Distefano R, Beane J, Tsichlis P, et al.
iScience
. 2024 Feb;
27(2):108810.
PMID: 38303722
tRNA-derived ncRNAs are a heterogeneous class of non-coding RNAs recently proposed to be active regulators of gene expression and be involved in many diseases, including cancer. Consequently, several online resources...
4.
Chavdoula E, Anastas V, La Ferlita A, Aldana J, Carota G, Spampinato M, et al.
Metabolism
. 2023 Nov;
150:155719.
PMID: 37935302
Introduction: KDM2B encodes a JmjC domain-containing histone lysine demethylase, which functions as an oncogene in several types of tumors, including TNBC. This study was initiated to address the cancer relevance...
5.
McRee S, Bayer A, Pietruska J, Tsichlis P, Hinds P
Cancers (Basel)
. 2023 Oct;
15(20).
PMID: 37894325
Despite recent advances in treatment, melanoma remains the deadliest form of skin cancer due to its highly metastatic nature. Melanomas harboring oncogenic BRAF mutations combined with PTEN loss exhibit unrestrained...
6.
La Ferlita A, Nigita G, Tsyba L, Palamarchuk A, Alaimo S, Pulvirenti A, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(44):e2307593120.
PMID: 37871223
Chronic lymphocytic leukemia (CLL) is one of the most diagnosed forms of leukemia worldwide and it is usually classified into two forms: indolent and aggressive. These two forms are characterized...
7.
McRee S, Bayer A, Pietruska J, Tsichlis P, Hinds P
bioRxiv
. 2023 Sep;
PMID: 37662310
Despite recent advances in treatment, melanoma remains the deadliest form of skin cancer, due to its highly metastatic nature. Melanomas harboring oncogenic BRAF mutations combined with PTEN loss exhibit unrestrained...
8.
Chavdoula E, Anastas V, La Ferlita A, Aldana J, Carota G, Spampinato M, et al.
bioRxiv
. 2023 Jul;
PMID: 37461630
Introduction: KDM2B encodes a JmjC domain-containing histone lysine demethylase, which functions as an oncogene in several types of tumors, including TNBC. This study was initiated to address the cancer relevance...
9.
Lapi I, Daskalaki M, Axarlis K, Paflioti E, Tsichlis P, Vergadi E, et al.
Curr Top Microbiol Immunol
. 2022 Oct;
436:165-196.
PMID: 36243844
Macrophages display an array of activation phenotypes depending on the activation signal and the cellular microenvironment. The type and magnitude of the response depend on signaling molecules as well as...
10.
La Ferlita A, Distefano R, Alaimo S, Beane J, Ferro A, Croce C, et al.
Cancers (Basel)
. 2022 Sep;
14(18).
PMID: 36139593
Lung cancer is the second most commonly diagnosed cancer and the leading cause of cancer deaths worldwide. Among its subtypes, lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) are...