Philip M Cummins
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Explore the profile of Philip M Cummins including associated specialties, affiliations and a list of published articles.
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55
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1427
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Recent Articles
1.
Kostyunina D, Rowan S, Pakhomov N, Dillon E, Rochfort K, Cummins P, et al.
Am J Respir Cell Mol Biol
. 2023 Feb;
68(5):551-565.
PMID: 36730645
Blood flow produces shear stress that homeostatically regulates the phenotype of pulmonary endothelial cells, exerting antiinflammatory and antithrombotic actions and maintaining normal barrier function. Hypoxia due to diseases, such as...
2.
Wallace R, Rochfort K, Barabas P, Curtis T, Uehara H, Ambati B, et al.
Vascul Pharmacol
. 2021 Sep;
141:106919.
PMID: 34583025
The Angiopoietin-1/2 system is an opportune target for therapeutic intervention in a wide range of vascular pathologies, particularly through its association with endothelium. The complex multi-domain structure of native human...
3.
Forde H, Harper E, Rochfort K, Wallace R, Davenport C, Smith D, et al.
Physiol Rep
. 2020 Oct;
8(20):e14612.
PMID: 33080110
Studies suggest that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has vasoprotective potential, as low levels of TRAIL cause accelerated vascular calcification, whereas exogenous TRAIL administration exhibits anti-atherosclerotic activity. The mechanism...
4.
Harper E, Rochfort K, Smith D, Cummins P
Mol Cell Biochem
. 2019 Nov;
464(1-2):111-117.
PMID: 31724123
Numerous studies have highlighted the causal link between over-production of reactive oxygen species (ROS) and cardiovascular complications such as vascular calcification (VC). Receptor-activator of nuclear factor-κB ligand (RANKL) has previously...
5.
Rochfort K, Carroll L, Barabas P, Curtis T, Ambati B, Barron N, et al.
Invest Ophthalmol Vis Sci
. 2019 Aug;
60(10):3547-3555.
PMID: 31415078
Purpose: Current treatments for diabetic retinopathy (DR) have considerable limitations, underpinning the need for new therapeutic options. In this article, the ability of an engineered angiopoietin-1 variant (COMP-Ang1) to ameliorate...
6.
Carroll L, Uehara H, Fang D, Choi S, Zhang X, Singh M, et al.
Invest Ophthalmol Vis Sci
. 2019 Jun;
60(7):2494-2502.
PMID: 31185088
Purpose: We determine whether intravitreal angiopoietin-1 combined with the short coiled-coil domain of cartilage oligomeric matrix protein by adeno-associated viral serotype 2 (AAV2.COMP-Ang1) delivery following the onset of vascular damage...
7.
Rowan S, Rochfort K, Piouceau L, Cummins P, ORourke M, McLoughlin P
Am J Physiol Lung Cell Mol Physiol
. 2018 May;
315(4):L476-L484.
PMID: 29792349
Fluid filtration in the pulmonary microcirculation depends on the hydrostatic and oncotic pressure gradients across the endothelium and the selective permeability of the endothelial barrier. Maintaining normal fluid balance depends...
8.
Harper E, Rochfort K, Forde H, Davenport C, Smith D, Cummins P
Cell Signal
. 2018 Apr;
47:142-150.
PMID: 29678621
Background: The intimal endothelium is known to condition the underlying medial smooth muscle cell (SMC) layer of the vessel wall, and is highly responsive to receptor-activator of nuclear factor-κB ligand...
9.
Davenport C, Harper E, Rochfort K, Forde H, Smith D, Cummins P
J Vasc Res
. 2018 Apr;
55(2):111-123.
PMID: 29635231
Receptor activator of nuclear factor-κB ligand (RANKL) promotes vascular calcification, while osteoprotegerin (OPG) opposes it by blocking RANKL activity. It remains unclear which vascular cell populations produce and secrete OPG/RANKL....
10.
Wallace R, Twomey L, Custaud M, Turner J, Moyna N, Cummins P, et al.
Mech Ageing Dev
. 2017 Nov;
174:76-85.
PMID: 29155255
The cardiovascular system is responsible for transport of blood and nutrients to tissues, and is pivotal to the physiological health and longevity. Epigenetic modification is a natural, age-associated process resulting...