TRAIL Inhibits Oxidative Stress in Human Aortic Endothelial Cells Exposed to Pro-inflammatory Stimuli

Overview

Journal Physiol Rep

Specialty Physiology

Date 2020 Oct 20

PMID 33080110

Citations 6

Authors

Hannah Forde

Emma Harper

Keith D Rochfort

Robert G Wallace

Colin Davenport

Diarmuid Smith

Philip M Cummins

Affiliations

Soon will be listed here.

Abstract

Studies suggest that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has vasoprotective potential, as low levels of TRAIL cause accelerated vascular calcification, whereas exogenous TRAIL administration exhibits anti-atherosclerotic activity. The mechanism of TRAIL-mediated vasoprotection remains unclear. We studied the effects of TRAIL (100 ng/ml) on human aortic endothelial cells (HAECs) exposed to pro-atherogenic conditions; (a) oscillatory shear stress (±10 dynes/cm ) using the ibidi µ-slide fluidic system; (b) pro-inflammatory injury, that is, tumor necrosis factor alpha (TNF-α, 100 ng/ml) and hyperglycemia (30 mM d-glucose). End-points examined included inflammatory gene expression and reactive oxygen species (ROS) formation. TRAIL shifted the net gene expression toward an antioxidant phenotype in HAECs exposed to oscillatory shear stress. TRAIL significantly reduced ROS formation in HAECs exposed to both TNF-α and hyperglycemia. Therefore, TRAIL appears to confer atheroprotective effects on the endothelium, at least in part, by reducing oxidative stress.

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References

Di Bartolo B, Chan J, Bennett M, Cartland S, Bao S, Tuch B . TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe ⁻/⁻ mice. Diabetologia. 2011; 54(12):3157-67. DOI: 10.1007/s00125-011-2308-0. View

Degli-Esposti M . To die or not to die--the quest of the TRAIL receptors. J Leukoc Biol. 1999; 65(5):535-42. DOI: 10.1002/jlb.65.5.535. View

Davenport C, Harper E, Rochfort K, Forde H, Smith D, Cummins P . RANKL Inhibits the Production of Osteoprotegerin from Smooth Muscle Cells under Basal Conditions and following Exposure to Cyclic Strain. J Vasc Res. 2018; 55(2):111-123. PMC: 6375687. DOI: 10.1159/000486787. View

Manuneedhi Cholan P, Cartland S, Dang L, Rayner B, Patel S, Thomas S . TRAIL protects against endothelial dysfunction in vivo and inhibits angiotensin-II-induced oxidative stress in vascular endothelial cells in vitro. Free Radic Biol Med. 2018; 126:341-349. DOI: 10.1016/j.freeradbiomed.2018.08.031. View

Tribble D, Barcellos-Hoff M, Chu B, Gong E . Ionizing radiation accelerates aortic lesion formation in fat-fed mice via SOD-inhibitable processes. Arterioscler Thromb Vasc Biol. 1999; 19(6):1387-92. DOI: 10.1161/01.atv.19.6.1387. View

Li J, Kirkiles-Smith N, McNiff J, Pober J . TRAIL induces apoptosis and inflammatory gene expression in human endothelial cells. J Immunol. 2003; 171(3):1526-33. DOI: 10.4049/jimmunol.171.3.1526. View

Dasari A, Bartholomew J, Volonte D, Galbiati F . Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 mitogen-activated protein kinase/Sp1-mediated activation of two GC-rich promoter elements. Cancer Res. 2006; 66(22):10805-14. PMC: 4288740. DOI: 10.1158/0008-5472.CAN-06-1236. View

Brooks A, Lelkes P, Rubanyi G . Gene expression profiling of human aortic endothelial cells exposed to disturbed flow and steady laminar flow. Physiol Genomics. 2002; 9(1):27-41. DOI: 10.1152/physiolgenomics.00075.2001. View

Fulda S, Gorman A, Hori O, Samali A . Cellular stress responses: cell survival and cell death. Int J Cell Biol. 2010; 2010:214074. PMC: 2825543. DOI: 10.1155/2010/214074. View

10.

Leon B, Maddox T . Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015; 6(13):1246-58. PMC: 4600176. DOI: 10.4239/wjd.v6.i13.1246. View

11.

Secchiero P, Corallini F, Ceconi C, Parrinello G, Volpato S, Ferrari R . Potential prognostic significance of decreased serum levels of TRAIL after acute myocardial infarction. PLoS One. 2009; 4(2):e4442. PMC: 2637972. DOI: 10.1371/journal.pone.0004442. View

12.

Didion S, Ryan M, Didion L, Fegan P, Sigmund C, Faraci F . Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res. 2002; 91(10):938-44. DOI: 10.1161/01.res.0000043280.65241.04. View

13.

Li X, Han W, Boini K, Xia M, Zhang Y, Li P . TRAIL death receptor 4 signaling via lysosome fusion and membrane raft clustering in coronary arterial endothelial cells: evidence from ASM knockout mice. J Mol Med (Berl). 2012; 91(1):25-36. PMC: 3537912. DOI: 10.1007/s00109-012-0968-y. View

14.

Cheang W, Wong W, Tian X, Yang Q, Lee H, He G . Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice. Cardiovasc Res. 2011; 92(2):267-75. DOI: 10.1093/cvr/cvr233. View

15.

True A, Olive M, Boehm M, San H, Westrick R, Raghavachari N . Heme oxygenase-1 deficiency accelerates formation of arterial thrombosis through oxidative damage to the endothelium, which is rescued by inhaled carbon monoxide. Circ Res. 2007; 101(9):893-901. DOI: 10.1161/CIRCRESAHA.107.158998. View

16.

Juan S, Lee T, Tseng K, Liou J, Shyue S, Wu K . Adenovirus-mediated heme oxygenase-1 gene transfer inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2001; 104(13):1519-25. DOI: 10.1161/hc3801.095663. View

17.

Zhang X, Zhuang J, Wu H, Chen Z, Su J, Chen S . Inhibitory effects of calcitonin gene-related peptides on experimental vein graft disease. Ann Thorac Surg. 2010; 90(1):117-23. DOI: 10.1016/j.athoracsur.2010.03.063. View

18.

Zauli G, Pandolfi A, Gonelli A, Di Pietro R, Guarnieri S, Ciabattoni G . Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sequentially upregulates nitric oxide and prostanoid production in primary human endothelial cells. Circ Res. 2003; 92(7):732-40. DOI: 10.1161/01.RES.0000067928.83455.9C. View

19.

Volpato S, Ferrucci L, Secchiero P, Corallini F, Zuliani G, Fellin R . Association of tumor necrosis factor-related apoptosis-inducing ligand with total and cardiovascular mortality in older adults. Atherosclerosis. 2010; 215(2):452-8. PMC: 3070040. DOI: 10.1016/j.atherosclerosis.2010.11.004. View

20.

Wang S, El-Deiry W . TRAIL and apoptosis induction by TNF-family death receptors. Oncogene. 2003; 22(53):8628-33. DOI: 10.1038/sj.onc.1207232. View