Philip J Spence
Overview
Explore the profile of Philip J Spence including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
370
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Recent Articles
1.
Herbert Mainero A, Spence P, Reece S, Kamiya T
Front Immunol
. 2023 Aug;
14:1171176.
PMID: 37646037
Decades of research have probed the molecular and cellular mechanisms that control the immune response to malaria. Yet many studies offer conflicting results on the functional impact of innate immunity...
2.
Bach F, Munoz Sandoval D, Mazurczyk M, Themistocleous Y, Rawlinson T, Harding A, et al.
J Clin Invest
. 2023 Aug;
133(20).
PMID: 37616070
BACKGROUNDThe biology of Plasmodium vivax is markedly different from that of P. falciparum; how this shapes the immune response to infection remains unclear. To address this shortfall, we inoculated human...
3.
Nastase A, Barrett M, Cardenas W, Cordeiro F, Zambrano M, Andrade J, et al.
PLoS Negl Trop Dis
. 2023 Jul;
17(7):e0011133.
PMID: 37486920
Acute febrile illnesses are still a major cause of mortality and morbidity globally, particularly in low to middle income countries. The aim of this study was to determine any possible...
4.
Salkeld J, Themistocleous Y, Barrett J, Mitton C, Rawlinson T, Payne R, et al.
Front Immunol
. 2022 Sep;
13:984323.
PMID: 36072606
Clinical Trial Registration: ClinicalTrials.gov, identifier NCT03906474, NCT02927145.
5.
Minassian A, Themistocleous Y, Silk S, Barrett J, Kemp A, Quinkert D, et al.
JCI Insight
. 2021 Oct;
6(23).
PMID: 34609964
Controlled human malaria infection (CHMI) provides a highly informative means to investigate host-pathogen interactions and enable in vivo proof-of-concept efficacy testing of new drugs and vaccines. However, unlike Plasmodium falciparum,...
6.
Nahrendorf W, Ivens A, Spence P
Elife
. 2021 Mar;
10.
PMID: 33752799
Immunity to malaria is often considered slow to develop but this only applies to defense mechanisms that function to eliminate parasites (resistance). In contrast, immunity to severe disease can be...
7.
Milne K, Ivens A, Reid A, Lotkowska M, OToole A, Sankaranarayanan G, et al.
Elife
. 2021 Mar;
10.
PMID: 33648633
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen...
8.
Smith N, Nahrendorf W, Sutherland C, Mooney J, Thompson J, Spence P, et al.
Front Immunol
. 2020 Dec;
11:587756.
PMID: 33329568
CD4 αβ T-cells are key mediators of the immune response to a first infection, undergoing extensive activation and splenic expansion during the acute phase of an infection. However, the clonality...
9.
Marr E, Milne R, Anar B, Girling G, Schwach F, Mooney J, et al.
Wellcome Open Res
. 2020 Jul;
5:71.
PMID: 32500098
The rodent parasite is an important model of malaria. The ability to produce chronic infections makes it particularly useful for investigating the development of anti- immunity, as well as features...
10.
Spence P, Brugat T, Langhorne J
PLoS Pathog
. 2015 Jul;
11(7):e1004987.
PMID: 26133171
No abstract available.