Jean Langhorne
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Explore the profile of Jean Langhorne including associated specialties, affiliations and a list of published articles.
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Articles
120
Citations
4376
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Recent Articles
1.
Badiane A, Ngom B, Ndiaye T, Cunningham D, Campbell J, Gaye A, et al.
Malar J
. 2024 May;
23(1):149.
PMID: 38750583
Background: Malaria elimination in Senegal requires accurate diagnosis of all Plasmodium species. Plasmodium falciparum is the most prevalent species in Senegal, although Plasmodium malariae, Plasmodium ovale, and recently Plasmodium vivax...
2.
Minutti C, Piot C, Pereira da Costa M, Chakravarty P, Rogers N, Huerga Encabo H, et al.
Nat Immunol
. 2024 Feb;
25(3):448-461.
PMID: 38351322
Conventional dendritic cells (cDCs) include functionally and phenotypically diverse populations, such as cDC1s and cDC2s. The latter population has been variously subdivided into Notch-dependent cDC2s, KLF4-dependent cDC2s, T-bet cDC2As and...
3.
Kimenyi K, Akinyi M, Mwikali K, Gilmore T, Mwangi S, Omer E, et al.
BMC Infect Dis
. 2024 Jan;
24(1):140.
PMID: 38287287
Background: Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections. There is limited information on how host-parasite interactions mediate the maintenance...
4.
Whiteside S, Grant F, Alvisi G, Clarke J, Tang L, Imianowski C, et al.
Sci Immunol
. 2023 Dec;
8(90):eabo5558.
PMID: 38100544
Regulatory T (T) cells contribute to immune homeostasis but suppress immune responses to cancer. Strategies to disrupt T cell-mediated cancer immunosuppression have been met with limited clinical success, but the...
5.
Cunningham D, Reid A, Hosking C, Deroost K, Tumwine-Downey I, Sanders M, et al.
BMC Res Notes
. 2023 Apr;
16(1):56.
PMID: 37076932
Objective: To analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated from the blood of infected mice. Results: Infected red...
6.
Tumwine-Downey I, Deroost K, Levy P, McLaughlin S, Hosking C, Langhorne J
Curr Res Immunol
. 2023 Jan;
4:100054.
PMID: 36593995
Advances in transcriptomics and proteomics have revealed that different life-cycle stages of the malaria parasite, share antigens, thus allowing for the possibility of eliciting immunity to a parasite life-cycle stage...
7.
Giorgalli M, Cunningham D, Broncel M, Sait A, Harrison T, Hosking C, et al.
Front Cell Infect Microbiol
. 2022 Jul;
12:877253.
PMID: 35782145
multigene families are thought to play important roles in the pathogenesis of malaria. genes comprise the largest multigene family in many species. However, their expression pattern and localisation remain to...
8.
Valletta J, Addy J, Reid A, Ndungu F, Bediako Y, Mwacharo J, et al.
Wellcome Open Res
. 2022 Mar;
6:22.
PMID: 35310901
After decades of research, our understanding of when and why individuals infected with develop clinical malaria is still limited. Correlates of immune protection are often sought through prospective cohort studies,...
9.
Addy J, Bediako Y, Ndungu F, Valetta J, Reid A, Mwacharo J, et al.
Wellcome Open Res
. 2022 Feb;
6:79.
PMID: 35141425
Studies of long-term malaria cohorts have provided essential insights into how interacts with humans, and influences the development of antimalarial immunity. Immunity to malaria is acquired gradually after multiple infections,...
10.
Little T, Cunningham D, Vandomme A, Lopez C, Amis S, Alder C, et al.
Malar J
. 2021 Nov;
20(1):445.
PMID: 34823519
Background: Plasmodium interspersed repeat (pir) is the largest multigene family in the genomes of most Plasmodium species. A variety of functions for the PIR proteins which they encode have been...