Philip J Lucas
Overview
Explore the profile of Philip J Lucas including associated specialties, affiliations and a list of published articles.
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19
Citations
1292
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Recent Articles
1.
Farthing D, Buxbaum N, Lucas P, Maglakelidze N, Oliver B, Wang J, et al.
Sci Rep
. 2017 Jun;
7(1):4043.
PMID: 28642474
Deuterated water (HO) is a label commonly used for safe quantitative measurement of deuterium enrichment into DNA of proliferating cells. More recently, it has been used for labeling proteins and...
2.
Williams K, Moore A, Lucas P, Wang J, Bare C, Gress R
Exp Hematol
. 2017 May;
52:40-49.
PMID: 28552733
Impaired immune reconstitution after hematopoietic stem cell transplantation (HSCT) is attributed in part to impaired thymopoiesis. Recent data suggest that precursor input may be a point of regulation for the...
3.
El-Kassar N, Flomerfelt F, Choudhury B, Hugar L, Chua K, Kapoor V, et al.
Int Immunol
. 2012 Aug;
24(10):661-71.
PMID: 22899673
IL-7 signaling is required for thymocyte development and its loss has a severe deleterious effect on thymus function. Thymocyte-stromal cell interactions and other mechanisms tightly regulate IL-7 expression. We show...
4.
Kim G, Ligons D, Hong C, Luckey M, Keller H, Tai X, et al.
J Immunol
. 2012 May;
188(12):5859-66.
PMID: 22593613
All T cells are dependent on IL-7 for their development and for homeostasis. Foxp3(+) regulatory T cells (Tregs) are unique among T cells in that they are dependent on IL-2....
5.
Casey K, Fraser K, Schenkel J, Moran A, Abt M, Beura L, et al.
J Immunol
. 2012 Apr;
188(10):4866-75.
PMID: 22504644
Differentiation and maintenance of recirculating effector memory CD8 T cells (T(EM)) depends on prolonged cognate Ag stimulation. Whether similar pathways of differentiation exist for recently identified tissue-resident effector memory T...
6.
Park J, Adoro S, Guinter T, Erman B, Alag A, Catalfamo M, et al.
Nat Immunol
. 2010 Feb;
11(3):257-64.
PMID: 20118929
Immature CD4(+)CD8(+) (double-positive (DP)) thymocytes are signaled via T cell antigen receptors (TCRs) to undergo positive selection and become responsive to intrathymic cytokines such as interleukin 7 (IL-7). We report...
7.
Williams K, Mella H, Lucas P, Williams J, Telford W, Gress R
Clin Transl Sci
. 2009 Sep;
2(4):279-85.
PMID: 19750208
Thymic epithelial cells (TECs) and dendritic cells are essential for the maintenance of thymopoiesis. Because these stromal elements define the progenitor niche, provide critical survival signals and growth factors, and...
8.
Williams K, Lucas P, Bare C, Wang J, Chu Y, Tayler E, et al.
Blood
. 2008 Aug;
112(8):3255-63.
PMID: 18694999
Although studies have demonstrated that androgen withdrawal increases thymic size, molecular mechanisms underlying this expansion remain largely unknown. We show that decreased androgen signaling leads to enhanced immigration of bone...
9.
Park J, Adoro S, Lucas P, Sarafova S, Alag A, Doan L, et al.
Nat Immunol
. 2007 Sep;
8(10):1049-59.
PMID: 17873878
T cell immunity requires the long-term survival of T cells that are capable of recognizing self antigens but are not overtly autoreactive. How this balance is achieved remains incompletely understood....
10.
Lucas P, Kim S, Mackall C, Telford W, Chu Y, Hakim F, et al.
Blood
. 2006 Jun;
108(8):2789-95.
PMID: 16788095
T-cell subpopulations, defined by their expression of CD4, CD8, naive, and memory cell-surface markers, occupy distinct homeostatic compartments that are regulated primarily by cytokines. CD8+ memory T cells, as defined...