Philip J Hajduk
Overview
Explore the profile of Philip J Hajduk including associated specialties, affiliations and a list of published articles.
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62
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3570
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Recent Articles
11.
Metz J, Hajduk P
Curr Opin Chem Biol
. 2010 Jul;
14(4):498-504.
PMID: 20609615
Many successful drugs bind to and modulate multiple targets in vivo. Successfully navigating protein-ligand polypharmacology will be a crucial and increasingly utilized component of pharmaceutical research. As publicly available databases...
12.
Swann S, Merta P, Kifle L, Groebe D, Sarris K, Hajduk P, et al.
Bioorg Med Chem Lett
. 2010 May;
20(19):5787-92.
PMID: 20471255
Herein we describe the identification and characterization of a class of molecules that are believed to extend into a region of p38 known as the 'switch pocket'. Although these molecules...
13.
Muchmore S, Edmunds J, Stewart K, Hajduk P
J Med Chem
. 2010 Mar;
53(13):4830-41.
PMID: 20329801
No abstract available.
14.
Brown S, Muchmore S, Hajduk P
Drug Discov Today
. 2009 Apr;
14(7-8):420-7.
PMID: 19340931
Although the development of computational models to aid drug discovery has become an integral part of pharmaceutical research, the application of these models often fails to produce the expected impact...
15.
Yu L, Edalji R, Harlan J, Holzman T, Lopez A, Labkovsky B, et al.
Biochemistry
. 2009 Feb;
48(9):1870-7.
PMID: 19216516
Alzheimer's disease (AD) is a neurodegenerative disorder that is linked to the presence of amyloid beta-peptides that can form insoluble fibrils or soluble oligomeric assemblies. Soluble forms are present in...
16.
Akritopoulou-Zanze I, Hajduk P
Drug Discov Today
. 2009 Jan;
14(5-6):291-7.
PMID: 19121409
Protein kinases continue to hold tremendous promise for therapeutic intervention, and the search for novel, safe and efficacious kinase inhibitors has intensified over the past decade. Given that most kinases...
17.
Chen J, Zhang X, Kort M, Huth J, Sun C, Miesbauer L, et al.
J Neurosci
. 2008 May;
28(19):5063-71.
PMID: 18463259
TRPA1 is an excitatory, nonselective cation channel implicated in somatosensory function, pain, and neurogenic inflammation. Through covalent modification of cysteine and lysine residues, TRPA1 can be activated by electrophilic compounds,...
18.
Muchmore S, Debe D, Metz J, Brown S, Martin Y, Hajduk P
J Chem Inf Model
. 2008 Apr;
48(5):941-8.
PMID: 18416545
A wide variety of computational algorithms have been developed that strive to capture the chemical similarity between two compounds for use in virtual screening and lead discovery. One limitation of...
19.
Gracias V, Ji Z, Akritopoulou-Zanze I, Abad-Zapatero C, Huth J, Song D, et al.
Bioorg Med Chem Lett
. 2008 Mar;
18(8):2691-5.
PMID: 18362070
We report the discovery of the pyrimido-diazepine scaffolds as novel adenine mimics. Structure-based design led to the discovery of analogs with potent inhibitory activity against receptor tyrosine kinases, such as...
20.
Hajduk P, Sauer D
J Med Chem
. 2008 Jan;
51(3):553-64.
PMID: 18173228
The results of a statistical analysis of more than 84,000 compounds from lead optimization programs against 30 different protein targets is presented, with a focus on the effects that different...