Philip Hahnfeldt
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Explore the profile of Philip Hahnfeldt including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Benzekry S, Lamont C, Beheshti A, Tracz A, Ebos J, Hlatky L, et al.
PLoS Comput Biol
. 2014 Aug;
10(8):e1003800.
PMID: 25167199
Despite internal complexity, tumor growth kinetics follow relatively simple laws that can be expressed as mathematical models. To explore this further, quantitative analysis of the most classical of these were...
12.
Gao X, McDonald J, Naidu M, Hahnfeldt P, Hlatky L
Stem Cells Int
. 2014 Jun;
2014:249309.
PMID: 24955094
Enrichment of cancer stem cells (CSCs) is thought to be responsible for glioblastoma multiforme (GBM) recurrence after radiation therapy. Simulation results from our agent-based cellular automata model reveal that the...
13.
Weekes S, Barker B, Bober S, Cisneros K, Cline J, Thompson A, et al.
Bull Math Biol
. 2014 May;
76(7):1762-82.
PMID: 24840956
Tumors are appreciated to be an intrinsically heterogeneous population of cells with varying proliferation capacities and tumorigenic potentials. As a central tenet of the so-called cancer stem cell hypothesis, most...
14.
Beheshti A, Peluso M, Lamont C, Hahnfeldt P, Hlatky L
Radiat Res
. 2014 Feb;
181(3):272-83.
PMID: 24568128
Proton radiation is touted for improved tumor targeting, over standard gamma radiation, due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory demonstrate that in...
15.
Wilkie K, Hahnfeldt P
Interface Focus
. 2014 Feb;
3(4):20130010.
PMID: 24511375
Cancer dormancy, a state in which cancer cells persist in a host without significant growth, is a natural forestallment of progression to manifest disease and is thus of great clinical...
16.
Benzekry S, Gandolfi A, Hahnfeldt P
PLoS One
. 2014 Jan;
9(1):e84249.
PMID: 24465399
Autopsy studies of adults dying of non-cancer causes have shown that virtually all of us possess occult, cancerous lesions. This suggests that, for most individuals, cancer will become dormant and...
17.
Hlatky L, Hahnfeldt P
Cancer Res
. 2013 Nov;
74(3):659-64.
PMID: 24272486
Over the last several decades, improved awareness of the prevalence of carcinogens in the environment, along with a growing appreciation of the complexity of the carcinogenesis process, has shifted policy...
18.
Benzekry S, Hahnfeldt P
J Theor Biol
. 2013 Jul;
335:235-44.
PMID: 23850479
Although optimal control theory has been used for the theoretical study of anti-cancerous drugs scheduling optimization, with the aim of reducing the primary tumor volume, the effect on metastases is...
19.
Rietman E, Friesen D, Hahnfeldt P, Gatenby R, Hlatky L, Tuszynski J
Theor Biol Med Model
. 2013 Jun;
10:39.
PMID: 23758735
Background: In this paper we propose a chemical physics mechanism for the initiation of the glycolytic switch commonly known as the Warburg hypothesis, whereby glycolytic activity terminating in lactate continues...
20.
Enderling H, Hlatky L, Hahnfeldt P
Front Oncol
. 2013 Apr;
3:76.
PMID: 23596563
In recent years cancer stem cells (CSCs) have been hypothesized to comprise only a minor subpopulation in solid tumors that drives tumor initiation, progression, and metastasis; the so-called "cancer stem...