Philip Hahnfeldt
Overview
Explore the profile of Philip Hahnfeldt including associated specialties, affiliations and a list of published articles.
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54
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1735
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Recent Articles
1.
Benzekry S, Lamont C, Barbolosi D, Hlatky L, Hahnfeldt P
Cancer Res
. 2017 Jul;
77(18):5183-5193.
PMID: 28729417
Interactions between different tumors within the same organism have major clinical implications, especially in the context of surgery and metastatic disease. Three main explanatory theories (competition, angiogenesis inhibition, and proliferation...
2.
Wilkie K, Hahnfeldt P
Bull Math Biol
. 2017 Jun;
79(6):1426-1448.
PMID: 28585066
Although the immune response is often regarded as acting to suppress tumor growth, it is now clear that it can be both stimulatory and inhibitory. The interplay between these competing...
3.
Benzekry S, Beheshti A, Hahnfeldt P, Hlatky L
Bio Protoc
. 2016 Jul;
5(21).
PMID: 27453916
In 1999, Hahnfeldt . proposed a mathematical model for tumor growth as dictated by reciprocal communications between tumor and its associated vasculature, introducing the idea that a tumor is supported...
4.
Gao X, Sishc B, Nelson C, Hahnfeldt P, Bailey S, Hlatky L
Front Oncol
. 2016 Jul;
6:138.
PMID: 27379202
The enrichment of putative CD44(+)/CD24(-/low) breast stem cell populations following exposure to ionizing radiation (IR) has been ascribed to their inherent radioresistance and an elevated frequency of symmetric division during...
5.
Sridharan D, Asaithamby A, Blattnig S, Costes S, Doetsch P, Dynan W, et al.
Life Sci Space Res (Amst)
. 2016 Jun;
9:19-47.
PMID: 27345199
Robust predictive models are essential to manage the risk of radiation-induced carcinogenesis. Chronic exposure to cosmic rays in the context of the complex deep space environment may place astronauts at...
6.
Beheshti A, Wage J, McDonald J, Lamont C, Peluso M, Hahnfeldt P, et al.
Oncotarget
. 2015 Oct;
6(34):35419-32.
PMID: 26497558
The concept of age-dependent host control of cancer development raises the natural question of how these effects manifest across the host tissue/organ types with which a tumor interacts, one important...
7.
Wage J, Ma L, Peluso M, Lamont C, Evens A, Hahnfeldt P, et al.
J Radiat Res
. 2015 Aug;
56(5):792-803.
PMID: 26253138
Age plays a crucial role in the interplay between tumor and host, with additional impact due to irradiation. Proton irradiation of tumors induces biological modulations including inhibition of angiogenic and...
8.
Poleszczuk J, Hahnfeldt P, Enderling H
PLoS One
. 2015 Mar;
10(3):e0120007.
PMID: 25785600
Anti-angiogenic cancer treatments induce tumor starvation and regression by targeting the tumor vasculature that delivers oxygen and nutrients. Mathematical models prove valuable tools to study the proof-of-concept, efficacy and underlying...
9.
Poleszczuk J, Hahnfeldt P, Enderling H
PLoS Comput Biol
. 2015 Mar;
11(3):e1004025.
PMID: 25742563
Cells of different organs at different ages have an intrinsic set of kinetics that dictates their behavior. Transformation into cancer cells will inherit these kinetics that determine initial cell and...
10.
Beheshti A, Benzekry S, McDonald J, Ma L, Peluso M, Hahnfeldt P, et al.
Cancer Res
. 2015 Mar;
75(6):1134-43.
PMID: 25732382
Aging is the major determinant of cancer incidence, which, in turn, is likely dictated in large part by processes that influence the progression of early subclinical (occult) cancers. However, there...