Philip H Howe
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Explore the profile of Philip H Howe including associated specialties, affiliations and a list of published articles.
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66
Citations
2129
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Recent Articles
1.
Elshaer M, Howley B, Howe P
Cancers (Basel)
. 2025 Mar;
17(5).
PMID: 40075632
Microtubule dynamics play a pivotal role in cancer progression and response to chemotherapeutics. Identifying regulators of microtubule stability can provide new therapeutic targets and predictive biomarkers for cancer treatment. We...
2.
Karam J, Frereux C, Mohanty B, Dalton A, Dincman T, Palanisamy V, et al.
J Biol Chem
. 2024 Sep;
300(11):107830.
PMID: 39342995
PCBP1, polycytosine (poly(C)) binding protein 1, an RNA and single-stranded DNA (ssDNA) binding protein, binds poly(C) DNA tracts but it remains unclear whether its ability to bind ssDNA contributes to...
3.
Vijayakumar A, Majumder M, Yin S, Brobbey C, Karam J, Howley B, et al.
Nucleic Acids Res
. 2024 May;
52(12):7225-7244.
PMID: 38709899
Emerging evidence indicates that arginine methylation promotes the stability of arginine-glycine-rich (RGG) motif-containing RNA-binding proteins (RBPs) and regulates gene expression. Here, we report that post-translational modification of FXR1 enhances the...
4.
Dincman T, Karam J, Giordano A, Li H, Drusbosky L, Gourdin T, et al.
Front Oncol
. 2024 Mar;
13:1202277.
PMID: 38450313
Purpose: Analysis of circulating tumor DNA (ctDNA) in patients with metastatic prostate cancer (mPC) provides an opportunity to identify and monitor genomic alterations during a patient's treatment course. We evaluated...
5.
PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness
Streitfeld W, Dalton A, Howley B, Howe P
Cancer Biol Ther
. 2023 Nov;
24(1):2271638.
PMID: 37927213
The poly(rC) binding protein 1 gene (PCBP1) encodes the heterogeneous nuclear ribonucleoprotein E1 (hnRNPE1), a nucleic acid-binding protein that plays a tumor-suppressive role in the mammary epithelium by regulating phenotypic...
6.
Brobbey C, Yin S, Liu L, Ball L, Howe P, Delaney J, et al.
Sci Rep
. 2023 Jul;
13(1):10752.
PMID: 37400460
Protein arginine methyltransferase 5 (PRMT5) catalyzes mono-methylation and symmetric di-methylation on arginine residues and has emerged as a potential antitumor target with inhibitors being tested in clinical trials. However, it...
7.
Ning W, Cheng D, Howe P, Bian C, Kamen D, Luo Z, et al.
J Autoimmun
. 2022 Jul;
131:102860.
PMID: 35810689
Objectives: There is an intricate interplay between the microbiome and the immune response impacting development of normal immunity and autoimmunity. However, we do not fully understand how the microbiome affects...
8.
Parikh R, Nadig S, Mehrotra S, Howe P, Gangaraju V
Heliyon
. 2022 Jun;
8(6):e09735.
PMID: 35747323
Over 2.4 million daily total tests are currently being performed for SARS-CoV-2, in the United States. The most common SARS-CoV-2 tests require RNA extraction and purification. Extraction of RNA is...
9.
Howley B, Mohanty B, Dalton A, Grelet S, Karam J, Dincman T, et al.
Oncogene
. 2022 Feb;
41(12):1679-1690.
PMID: 35102251
The epithelial to mesenchymal transition (EMT), a process that is aberrantly activated in cancer and facilitates metastasis to distant organs, requires coordinated transcriptional and post-transcriptional control of gene expression. The...
10.
Grelet S, Frereux C, Obellianne C, Noguchi K, Howley B, Dalton A, et al.
Life Sci Alliance
. 2021 Nov;
5(2).
PMID: 34810279
Metastasis is the leading driver of cancer-related death. Tumor cell plasticity associated with the epithelial-mesenchymal transition (EMT), an embryonic program also observed in carcinomas, has been proposed to explain the...