Philip F Watson
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Explore the profile of Philip F Watson including associated specialties, affiliations and a list of published articles.
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23
Citations
324
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Recent Articles
1.
Huang L, Bon H, Maamra M, Holmes T, Atkinson J, Cain K, et al.
PLoS One
. 2024 May;
19(5):e0298864.
PMID: 38753630
Fibrotic remodeling is the primary driver of functional loss in chronic kidney disease, with no specific anti-fibrotic agent available for clinical use. Transglutaminase 2 (TG2), a wound response enzyme that...
2.
Maamra M, Benayad O, Matthews D, Kettleborough C, Atkinson J, Cain K, et al.
Br J Pharmacol
. 2021 Dec;
179(11):2697-2712.
PMID: 34879432
Background And Purpose: Transglutaminase type 2 (TG2) catalyses formation of ε-(γ-glutamyl)-lysine bonds between proteins, including those of the extracellular matrix (ECM). Elevated extracellular TG2 leads to accelerated ECM deposition and...
3.
Kemp E, Ajjan R, Metcalfe R, Watson P, Weetman A
Clin Endocrinol (Oxf)
. 2015 May;
83(5):726-32.
PMID: 25940130
Objectives: Cytokines have an important role in orchestrating the pathophysiology in autoimmune thyroid disease. The aim of the current study was to analyse the expression of interleukin (IL)-14 and IL-16...
4.
Kemp E, Sandhu H, Watson P, Weetman A
J Clin Endocrinol Metab
. 2013 Jan;
98(2):E309-13.
PMID: 23322815
Context: Pendrin is a transmembrane protein located at the apical end of the thyrocyte in which it mediates the efflux of iodide through the thyroid follicular cell. Recently pendrin was...
5.
Chou C, Streets A, Watson P, Huang L, Verderio E, Johnson T
J Biol Chem
. 2011 Jun;
286(31):27825-35.
PMID: 21652693
Transglutaminase type 2 (TG2) catalyzes the formation of an ε-(γ-glutamyl)-lysine isopeptide bond between adjacent peptides or proteins including those of the extracellular matrix (ECM). Elevated extracellular TG2 leads to accelerated...
6.
Kemp E, Emhemad S, Akhtar S, Watson P, Gawkrodger D, Weetman A
Exp Dermatol
. 2010 Dec;
20(1):35-40.
PMID: 21158937
Vitiligo is an acquired idiopathic hypomelanotic skin disorder characterised by depigmented macules because of loss of cutaneous melanocytes. Although the exact cause of vitiligo remains obscure, evidence suggests that autoimmunity...
7.
Kemp E, Gavalas N, Krohn K, Brown E, Watson P, Weetman A
J Clin Endocrinol Metab
. 2009 Oct;
94(12):4749-56.
PMID: 19837919
Context: Autoimmune polyendocrine syndrome type 1 (APS1) is an autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene. Hypoparathyroidism occurs in 80% of patients with APS1 and...
8.
Waterman E, Gawkrodger D, Watson P, Weetman A, Kemp E
J Invest Dermatol
. 2009 Jul;
130(1):230-40.
PMID: 19587696
Vitiligo is an acquired idiopathic hypomelanotic disorder characterized by circumscribed depigmented macules resulting from the loss of cutaneous melanocytes. Although the exact cause of vitiligo remains obscure, autoimmunity may play...
9.
Kemp E, Gavalas N, Akhtar S, Krohn K, Pallais J, Brown E, et al.
J Bone Miner Res
. 2009 Jul;
25(1):132-40.
PMID: 19580466
Previously, we have demonstrated the presence of anti-calcium-sensing receptor (CaSR) antibodies in patients with autoimmune polyglandular syndrome type 1 (APS1), a disease that is characterized in part by hypoparathyroidism involving...
10.
Gavalas N, Gottumukkala R, Gawkrodger D, Watson P, Weetman A, Kemp E
Exp Dermatol
. 2009 Mar;
18(5):454-63.
PMID: 19320743
The melanin-concentrating hormone receptor 1 (MCHR1) has been identified as a B cell autoantigen in vitiligo with antibodies to the receptor detectable in binding and function-blocking assays. Two epitope domains...