Philip E Ryan
Overview
Explore the profile of Philip E Ryan including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
11
Citations
327
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Daniels S, Liyasova M, Kales S, Nau M, Ryan P, Green J, et al.
PLoS One
. 2019 Jul;
14(7):e0219143.
PMID: 31260484
Receptor Tyrosine Kinase (RTK) signaling is essential for normal biological processes and disruption of this regulation can lead to tumor initiation and progression. Cbl proteins (Cbl, Cbl-b and Cbl-c) are...
2.
Liyasova M, Ma K, Voeller D, Ryan P, Chen J, Klevit R, et al.
PLoS One
. 2019 May;
14(5):e0216967.
PMID: 31120930
Many receptor tyrosine kinases (RTKs, such as EGFR, MET) are negatively regulated by ubiquitination and degradation mediated by Cbl proteins, a family of RING finger (RF) ubiquitin ligases (E3s). Loss...
3.
Gilliland C, Sittampalam G, Wang P, Ryan P
Biochem Mol Biol Educ
. 2016 May;
45(1):13-24.
PMID: 27231204
Translational science is an emerging field that holds great promise to accelerate the development of novel medical interventions. As the field grows, so does the demand for highly trained biomedical...
4.
Ryan P, Kales S, Yadavalli R, Nau M, Zhang H, Lipkowitz S
PLoS One
. 2012 Nov;
7(11):e49428.
PMID: 23145173
Cbl proteins (Cbl, Cbl-b and Cbl-c) are ubiquitin ligases that are critical regulators of tyrosine kinase signaling. In this study we identify a new Cbl-c interacting protein, Hydrogen peroxide Induced...
5.
Kales S, Ryan P, Lipkowitz S
Nat Struct Mol Biol
. 2012 Feb;
19(2):131-3.
PMID: 22301873
No abstract available.
6.
Ryan P, Sivadasan-Nair N, Nau M, Nicholas S, Lipkowitz S
J Biol Chem
. 2010 Jun;
285(31):23687-98.
PMID: 20525694
Cbl proteins are ubiquitin ligases (E3s) that play a significant role in regulating tyrosine kinase signaling. There are three mammalian family members: Cbl, Cbl-b, and Cbl-c. All have a highly...
7.
Kales S, Ryan P, Nau M, Lipkowitz S
Cancer Res
. 2010 May;
70(12):4789-94.
PMID: 20501843
Cbl was originally discovered in 1989 as the cellular homolog of the v-Cbl oncogene, the transforming gene of the Cas NS-1 murine retrovirus that causes myeloid leukemia and lymphomas in...
8.
Ryan P, Davies G, Nau M, Lipkowitz S
Trends Biochem Sci
. 2006 Jan;
31(2):79-88.
PMID: 16406635
Cbl proteins are regulators of signal transduction through many pathways and, consequently, regulate cell function and development. They are ubiquitin ligases that ubiquitinate and target many signaling molecules for degradation....
9.
Tepper C, Gregg J, Shi X, Vinall R, Baron C, Ryan P, et al.
Prostate
. 2005 Jul;
65(4):375-89.
PMID: 16037992
Background: Tumor suppressor p53 mutations are associated with the transition of prostate cancer to metastatic, hormone-refractory disease and stable expression of p53 gain-of-function (p53GOF) alleles support growth of LNCaP in...
10.
Munitic I, Ryan P, Ashwell J
J Immunol
. 2005 Mar;
174(7):4010-8.
PMID: 15778358
The commitment of naive T cells to proliferate is a function of the strength and duration of stimuli mediated by the TCR and coreceptors. Ranges of 2-20 h of stimulation...