Philip C N Chiu
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Explore the profile of Philip C N Chiu including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
The regulatory role of placental extracellular vesicle on trophoblast and endothelial cell functions
Bai K, Li X, Guo Y, Shang Y, Lin L, Chiu P, et al.
Front Cell Dev Biol
. 2025 Feb;
13:1528714.
PMID: 39996028
Extracellular vesicles (EVs) are cell-derived, membrane-bound vesicles that carry molecular cargo to facilitate communication between cells. During pregnancy, EVs are secreted by the syncytiotrophoblast layer of the placenta villi, where...
2.
Liu J, Zeng Q, Duan Y, Yeung W, Li R, Ng E, et al.
Front Immunol
. 2024 Oct;
15:1456171.
PMID: 39434884
B cells constitute a diverse and adaptable immune cell population with functions that can vary according to the environment and circumstances. The involvement of B cells in pregnancy, as well...
3.
Li T, Li R, Ng E, Yeung W, Chiu P, Chan R
Front Immunol
. 2024 May;
15:1378863.
PMID: 38765018
Background: At menstruation, the functional layer of the human endometrium sheds off due to the trigger of the release of inflammatory factors, including interleukin 6 (IL-6), as a result of...
4.
Li Y, Sang Y, Chang Y, Xu C, Lin Y, Zhang Y, et al.
Circulation
. 2024 Feb;
149(21):1670-1688.
PMID: 38314577
Background: Preeclampsia is a serious disease of pregnancy that lacks early diagnosis methods or effective treatment, except delivery. Dysregulated uterine immune cells and spiral arteries are implicated in preeclampsia, but...
5.
Zhang Q, Lee C, Yang T, Li J, Zeng Q, Liu X, et al.
Sci Adv
. 2023 Nov;
9(44):eadi4777.
PMID: 37922358
Early-onset preeclampsia (EOPE) is a severe pregnancy complication associated with defective trophoblast differentiation and functions at implantation, but manifestation of its phenotypes is in late pregnancy. There is no reliable...
6.
Zhuang B, Cao D, Li T, Liu X, Lyu M, Wang S, et al.
BMC Genomics
. 2023 Oct;
24(1):618.
PMID: 37853336
Background: Extravillous trophoblast cell (EVT) differentiation and its communication with maternal decidua especially the leading immune cell type natural killer (NK) cell are critical events for placentation. However, appropriate in...
7.
Lin L, Bai K, Li J, Chiu P, Lee C
J Reprod Immunol
. 2023 Oct;
160:104158.
PMID: 37801890
The human endometrial gland plays a vital role in maternal immune tolerance and placental development. Decidual macrophages are the major phagocytic cells that regulate tissue remodeling during pregnancy. This study...
8.
Zhong J, Li J, Burton G, Koistinen H, Cheung K, Ng E, et al.
Hum Reprod Update
. 2023 Sep;
30(1):81-108.
PMID: 37699855
Background: The establishment of maternal-fetal crosstalk is vital to a successful pregnancy. Glycosylation is a post-translational modification in which glycans (monosaccharide chains) are attached to an organic molecule. Glycans are...
9.
Leung E, Lee B, Lee C, Tian X, Lam K, Li R, et al.
Front Endocrinol (Lausanne)
. 2023 Apr;
14:1135973.
PMID: 37020592
Human fertilization begins when a capacitated spermatozoon binds to the zona pellucida (ZP) surrounding a mature oocyte. Defective spermatozoa-ZP interaction contributes to male infertility and is a leading cause of...
10.
Zhuang B, Cao D, Liu X, Wang L, Lin X, Duan Y, et al.
Front Immunol
. 2023 Apr;
14:1130308.
PMID: 37006248
The human placenta is a unique temporary organ with a mysterious immune tolerance. The formation of trophoblast organoids has advanced the study of placental development. HLA-G is uniquely expressed in...