Markku Seppala
Overview
Explore the profile of Markku Seppala including associated specialties, affiliations and a list of published articles.
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45
Citations
600
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0
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Recent Articles
1.
Selenius J, Silveira P, von Bonsdorff M, Lahti J, Koistinen H, Koistinen R, et al.
Diabetes Metab J
. 2024 Mar;
48(5):960-970.
PMID: 38527457
Backgruound: To investigate associations between variations in the co-expression-based brain insulin receptor polygenic score and cardiometabolic risk factors and diabetes mellitus. Methods: This cross-sectional study included 1,573 participants from the...
2.
Vijayan M, Lee C, Wong V, Wang X, Bai K, Wu J, et al.
J Cell Sci
. 2020 Jun;
133(14).
PMID: 32513821
Decidual macrophages constitute 20-30% of the total leukocytes in the uterus of pregnant women, regulating the maternal immune tolerance and placenta development. Abnormal number or activities of decidual macrophages (dMs)...
3.
Lee C, Vijayan M, Wang X, Lam K, Koistinen H, Seppala M, et al.
Hum Reprod
. 2019 Jan;
34(4):689-701.
PMID: 30597092
Study Question: Does glycodelin-A (GdA) induce conversion of human peripheral blood CD16-CD56bright natural killer (NK) cells to decidual NK (dNK) cells to facilitate placentation? Summary Answer: GdA binds to blood...
4.
Lee C, Lam K, Vijayan M, Koistinen H, Seppala M, Ng E, et al.
Am J Reprod Immunol
. 2016 Jan;
75(3):290-7.
PMID: 26757357
Successful pregnancy depends largely on adequate placentation and maternal tolerance of the fetus. Glycodelin-A is a glycoprotein abundant in the decidua during early pregnancy. It plays an important role in...
5.
Lee C, Li K, Lam K, Ng E, Koistinen H, Seppala M, et al.
Mol Reprod Dev
. 2014 Apr;
81(6):482-3.
PMID: 24733737
No abstract available.
6.
Lee C, Lam E, Lam K, Koistinen H, Seppala M, Ng E, et al.
J Biol Chem
. 2012 Sep;
287(44):36999-7009.
PMID: 22977256
Macrophages represent the second major type of decidual leukocytes at the fetomaternal interface. Changes in macrophage number and activity are associated with fetal loss and pregnancy complications. Glycodelin-A (GdA) is...
7.
Lam K, Chiu P, Lee C, Pang R, Leung C, Koistinen H, et al.
J Biol Chem
. 2011 Sep;
286(43):37118-27.
PMID: 21880722
During placentation, the cytotrophoblast differentiates into the villous cytotrophoblast and the extravillous cytotrophoblast. The latter invades the decidualized endometrium. Glycodelin-A (GdA) is abundantly synthesized by the decidua but not the...
8.
Lee C, Lam K, Koistinen H, Seppala M, Kurpisz M, Fernandez N, et al.
J Reprod Immunol
. 2011 Jun;
90(1):29-34.
PMID: 21641661
Glycodelin-A (GdA) is a glycoprotein secreted from the endometrial glands and decidual glandular epithelium. Given its abundance and ubiquitous distribution in the first trimester uterus, GdA may be involved in...
9.
Lee C, Chiu P, Pang P, Chu I, Lee K, Koistinen R, et al.
Diabetes
. 2011 Feb;
60(3):909-17.
PMID: 21300843
Objective: Gestational diabetes mellitus (GDM) is a common metabolic disorder of pregnancy. Patients with GDM are at risk for high fetal mortality and gestational complications associated with reduced immune tolerance...
10.
Lee C, Chiu P, Lam K, Siu S, Chu I, Koistinen R, et al.
Hum Reprod
. 2011 Jan;
26(3):517-26.
PMID: 21227941
Background: The maternal-fetal interface has a unique immunological response towards the implanting placenta. It is generally accepted that a T-helper type-2 (Th-2) cytokine prevailing environment is important in pregnancy. The...