Peter U Mayerhofer
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Explore the profile of Peter U Mayerhofer including associated specialties, affiliations and a list of published articles.
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15
Citations
224
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Recent Articles
1.
Farelo M, Korrou-Karava D, Brooks K, Russell T, Maringer K, Mayerhofer P
Viruses
. 2022 Feb;
14(2).
PMID: 35215846
Flaviviruses such as dengue virus (DENV) and Zika virus (ZIKV) have evolved sophisticated mechanisms to suppress the host immune system. For instance, flavivirus infections were found to sabotage peroxisomes, organelles...
2.
Gerard S, Hall B, Zaki A, Corfield K, Mayerhofer P, Costa C, et al.
Mol Cell
. 2020 Jul;
79(3):406-415.e7.
PMID: 32692975
Protein secretion in eukaryotes and prokaryotes involves a universally conserved protein translocation channel formed by the Sec61 complex. Unrelated small-molecule natural products and synthetic compounds inhibit Sec61 with differential effects...
3.
Human Peroxin PEX3 Is Co-translationally Integrated into the ER and Exits the ER in Budding Vesicles
Mayerhofer P, Bano-Polo M, Mingarro I, Johnson A
Traffic
. 2015 Nov;
17(2):117-30.
PMID: 26572236
The long-standing paradigm that all peroxisomal proteins are imported post-translationally into pre-existing peroxisomes has been challenged by the detection of peroxisomal membrane proteins (PMPs) inside the endoplasmic reticulum (ER). In...
4.
Mayerhofer P
Biochim Biophys Acta
. 2015 Sep;
1863(5):870-80.
PMID: 26392202
The importance of peroxisomes is highlighted by severe inherited human disorders linked to impaired peroxisomal biogenesis. Besides the simple architecture of these ubiquitous and dynamic organelles, their biogenesis is surprisingly...
5.
Lin J, Eggensperger S, Hank S, Wycisk A, Wieneke R, Mayerhofer P, et al.
PLoS Pathog
. 2014 Dec;
10(12):e1004554.
PMID: 25503639
Coevolution of viruses and their hosts represents a dynamic molecular battle between the immune system and viral factors that mediate immune evasion. After the abandonment of smallpox vaccination, cowpox virus...
6.
Mayerhofer P, Tampe R
J Mol Biol
. 2014 Sep;
427(5):1102-18.
PMID: 25224907
Protein homeostasis results in a steady supply of peptides, which are further degraded to fuel protein synthesis or metabolic needs of the cell. In higher vertebrates, a small fraction of...
7.
Wycisk A, Lin J, Loch S, Hobohm K, Funke J, Wieneke R, et al.
J Biol Chem
. 2011 Oct;
286(48):41402-41412.
PMID: 21984826
Virus-infected cells are eliminated by cytotoxic T lymphocytes, which recognize viral epitopes displayed on major histocompatibility complex class I molecules at the cell surface. Herpesviruses have evolved sophisticated strategies to...
8.
Mayerhofer P, Cook J, Wahlman J, Pinheiro T, Moore K, Lord J, et al.
J Biol Chem
. 2009 Feb;
284(15):10232-42.
PMID: 19211561
After endocytic uptake by mammalian cells, the heterodimeric plant toxin ricin is transported to the endoplasmic reticulum (ER), where the ricin A chain (RTA) must cross the ER membrane to...
9.
Maier E, Mayerhofer P, Asheuer M, Kohler W, Rothe M, Muntau A, et al.
Biochem Biophys Res Commun
. 2008 Oct;
377(1):176-80.
PMID: 18834860
Strikingly variable clinical phenotypes can be found in X-linked adrenoleukodystrophy (X-ALD) even with the same ABCD1 mutation. ABCD2 is the closest homolog to ABCD1. Since ABCD2 overexpression complements the loss...
10.
Stadler S, Polanetz R, Maier E, Heidenreich S, Niederer B, Mayerhofer P, et al.
Hum Mutat
. 2006 Jul;
27(8):748-59.
PMID: 16835865
New technology enables expansion of newborn screening (NBS) of inborn errors aimed to prevent adverse outcome. In conditions with a large share of asymptomatic phenotypes, the potential harm created by...