Peter Satzer
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Explore the profile of Peter Satzer including associated specialties, affiliations and a list of published articles.
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20
Citations
126
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Recent Articles
11.
Dutra G, Komuczki D, Jungbauer A, Satzer P
Eng Life Sci
. 2020 Jul;
20(7):265-274.
PMID: 32647505
The capture of recombinant antibodies from cell culture broth is the first critical step of downstream processing. We were able to develop a precipitation-based method for the capture and purification...
12.
Krepper W, Burgstaller D, Jungbauer A, Satzer P
Biotechnol Prog
. 2019 Oct;
36(2):e2928.
PMID: 31622530
Antibodies of the IgG2 subclass were captured from the clarified cell culture fluid either by protein A chromatography or by polyethylene glycol precipitation. The captured intermediates were stored as neutralized...
13.
Burgstaller D, Jungbauer A, Satzer P
Biotechnol Bioeng
. 2019 Jan;
116(5):1053-1065.
PMID: 30636284
Continuous precipitation is a new unit operation for the continuous capture of antibodies. The capture step is based on continuous precipitation with PEG6000 and Zn in a tubular reactor integrated...
14.
Burgstaller D, Krepper W, Haas J, Maszelin M, Mohoric J, Pajnic K, et al.
J Chem Technol Biotechnol
. 2018 Jul;
93(7):1881-1890.
PMID: 30008503
Background: Integrated continuous production technology is of great interest in biopharmaceutical industry. Efficient, flexible and cost effective methods for continuous cell removal have to be developed, before a fully continuous...
15.
Satzer P, Sommer R, Paulsson J, Rodler A, Zehetner R, Hofstadter K, et al.
J Sep Sci
. 2018 Jun;
41(15):3051-3059.
PMID: 29873445
We developed a novel analytical method for concentration determination of tandem single-chain antibody diphtheria toxin (immunotoxin). The method is based on polymethacrylate monoliths with Protein L ligands as the binding...
16.
Krepper W, Satzer P, Beyer B, Jungbauer A
J Chromatogr A
. 2018 Apr;
1551:59-68.
PMID: 29625770
Staphylococcal protein A affinity chromatography is a well-established platform for purification of clinical-grade antibodies. The wild type ligand has been mutated to improve caustic stability, elution behavior, and/or to increase...
17.
Satzer P, Jungbauer A
J Sep Sci
. 2018 Jan;
41(8):1791-1797.
PMID: 29330912
The high-throughput analysis of antibodies from processes can be enhanced when the linear range is expanded and sample preparation is kept to a minimum. We developed a fast chromatography method...
18.
Satzer P, Svec F, Sekot G, Jungbauer A
Eng Life Sci
. 2016 Aug;
16(3):238-246.
PMID: 27478430
The use of nanomaterials in bioapplications demands a detailed understanding of protein-nanoparticle interactions. Proteins can undergo conformational changes while adsorbing onto nanoparticles, but studies on the impact of particle size...
19.
Tscheliessnig A, Satzer P, Hammerschmidt N, Schulz H, Helk B, Jungbauer A
J Biotechnol
. 2014 Aug;
188:17-28.
PMID: 25087738
Currently, the golden standard for the purification of recombinant humanized antibodies (rhAbs) from CHO cell culture is protein A chromatography. However, due to increasing rhAbs titers alternative methods have come...
20.
Satzer P, Wellhoefer M, Jungbauer A
J Chromatogr A
. 2014 May;
1349:44-9.
PMID: 24866563
For scale up and efficient production of protein loaded nanoparticles continuous separation by size exclusion chromatography in simulated moving bed (SMB) mode helps do reduce unbound protein concentration and increase...