Peter Saffrey
Overview
Explore the profile of Peter Saffrey including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
412
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Recent Articles
1.
Scott M, Korfi K, Saffrey P, Hopcroft L, Kinstrie R, Pellicano F, et al.
Cancer Discov
. 2016 Sep;
6(11):1248-1257.
PMID: 27630125
Significance: In CML, TKI-persistent LSCs remain an obstacle to cure, and approaches to eradicate them remain a significant unmet clinical need. We demonstrate that EZH2 and H3K27me3 reprogramming is important...
2.
Zhou Y, Kurukuti S, Saffrey P, Vukovic M, Michie A, Strogantsev R, et al.
Blood
. 2013 Nov;
122(26):4199-209.
PMID: 24200685
TAL1 is an important regulator of hematopoiesis and its expression is tightly controlled despite complexities in its genomic organization. It is frequently misregulated in T-cell acute lymphoblastic leukemia (T-ALL), often...
3.
Saunders C, Miller N, Soden S, Dinwiddie D, Noll A, Alnadi N, et al.
Sci Transl Med
. 2012 Oct;
4(154):154ra135.
PMID: 23035047
Monogenic diseases are frequent causes of neonatal morbidity and mortality, and disease presentations are often undifferentiated at birth. More than 3500 monogenic diseases have been characterized, but clinical testing is...
4.
Dhami P, Saffrey P, Bruce A, Dillon S, Chiang K, Bonhoure N, et al.
PLoS One
. 2010 Sep;
5(8):e12339.
PMID: 20808788
It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons ("exon-intron marking"), linking chromatin structure and function to...
5.
Saffrey P, Orton R
BMC Syst Biol
. 2009 Mar;
3:34.
PMID: 19292901
Background: Computational modelling has become an important tool in understanding biological systems such as signalling pathways. With an increase in size complexity of models comes a need for techniques to...