Peter P Fu
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Explore the profile of Peter P Fu including associated specialties, affiliations and a list of published articles.
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127
Citations
2110
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Recent Articles
1.
He X, Xia Q, Bryant M, Fu P
J Environ Sci Health C Toxicol Carcinog
. 2024 Nov;
:1-16.
PMID: 39545694
Pyrrolizidine alkaloids (PAs) form a family of toxic and carcinogenic phytochemicals found in plants worldwide. The metabolism of toxic PAs, both and , generates four (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5-pyrrolizine (DHP)-derived DNA adducts, namely,...
2.
Pan Y, Ma J, Zhao H, Fu P, Lin G
Food Chem Toxicol
. 2023 Jun;
178:113903.
PMID: 37390955
Pyrrolizidine alkaloids (PAs) are phytotoxins distributed in ∼6000 plant species. PA-contaminated/containing foodstuffs/herbs/supplements pose a potential threat to human health. Various regulatory authorities established different PA margins of exposure assuming an...
3.
He X, Xia Q, Zhu L, He Y, Bryant M, Lin G, et al.
Chem Res Toxicol
. 2023 Jan;
36(2):243-250.
PMID: 36705520
1,2-Unsaturated pyrrolizidine alkaloids (PAs) are carcinogenic phytochemicals. We previously determined that carcinogenic PAs and PA N-oxides commonly form a set of four (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5-pyrrolizine (DHP)-DNA adducts, namely, DHP-dG-3, DHP-dG-4, DHP-dA-3, and...
4.
Jiang X, Boudreau M, Fu P, Yin J
J Environ Sci Health C Toxicol Carcinog
. 2022 Jul;
39(4):435-459.
PMID: 35895951
Nano-metals, nano-metal oxides, and carbon-based nanomaterials exhibit superior solar-to-chemical/photo-electron transfer properties and are potential candidates for environmental remediations and energy transfer. Recent research effort focuses on enhancing the efficiency of...
5.
He X, Xia Q, Shi Q, Fu P
J Environ Sci Health C Toxicol Carcinog
. 2022 Jul;
39(4):357-372.
PMID: 35895950
We recently established a genotoxic mechanism mediated by a set of (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5-pyrrolizine (DHP)-DNA adducts, which lead to pyrrolizidine alkaloid (PA)-induced liver tumor initiation. This mechanism is involved in the metabolism...
6.
Zhu L, Xue J, He Y, Xia Q, Fu P, Lin G
Toxins (Basel)
. 2022 Jun;
14(6).
PMID: 35737038
Pyrrolizidine alkaloids (PAs) have been found in over 6000 plants worldwide and represent the most common hepatotoxic phytotoxins. Catalyzed by hepatic cytochrome P450 enzymes, PAs are metabolized into reactive pyrrolic...
7.
Wang Z, Ma J, Yao S, He Y, Miu K, Xia Q, et al.
Front Pharmacol
. 2022 Apr;
13:850859.
PMID: 35370657
Misuse of pyrrolizidine alkaloid (PA)-containing plants or consumption of PA-contaminated foodstuffs causes numerous poisoning cases in humans yearly, while effective therapeutic strategies are still limited. PA-induced liver injury was initiated...
8.
Zhu L, Zhang C, Zhang W, Xia Q, Ma J, He X, et al.
Arch Toxicol
. 2021 Aug;
95(10):3191-3204.
PMID: 34390356
Pyrrolizidine alkaloids (PAs) have been found in over 6000 plants worldwide and represent the most common hepatotoxic phytotoxins. Currently, a definitive diagnostic method for PA-induced liver injury (PA-ILI) is lacking....
9.
Guo X, Zhang S, Dial S, Boudreau M, Xia Q, Fu P, et al.
Toxicol Res (Camb)
. 2021 May;
3(6):487-496.
PMID: 33953902
A 2-year cancer bioassay in rodents with a preparation of whole leaf extract administered in drinking water showed clear evidence of carcinogenic activity. To provide insight into the identity and...
10.
He X, Xia Q, Gamboa da Costa G, Lin G, Fu P
Chem Res Toxicol
. 2021 Mar;
34(3):929.
PMID: 33646757
No abstract available.