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Peter P Fu

Explore the profile of Peter P Fu including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 127
Citations 2110
Followers 0
Related Specialties
Toxicology
Environmental Health
Pharmacology
Top 10 Co-Authors
Qingsu Xia
Ge Lin
Hongtao Yu
Jun-Jie Yin
Ming W Chou
Xiaobo He
Jian Yan
Wayne G Wamer
Yuewei Zhao
Paul C Howard
Published In
Chem Res Toxicol
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev
Int J Environ Res Public Health
J Food Drug Anal
Toxicol Lett
Affiliations
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Recent Articles
11.
Comprehensive investigation and risk study on pyrrolizidine alkaloid contamination in Chinese retail honey
He Y, Zhu L, Ma J, Wong L, Zhao Z, Ye Y, et al.
Environ Pollut . 2020 Dec; 267:115542. PMID: 33254676
Pyrrolizidine alkaloids (PAs) are common phytotoxins. We performed the first comprehensive investigation on PA contamination in Chinese honeys. LC-MS analysis revealed that 58% of 255 honey samples purchased from 17...
12.
Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China
Zhu L, Zhang C, Li D, Chen H, Ma J, Gao H, et al.
Acta Pharmacol Sin . 2020 Nov; 42(8):1212-1222. PMID: 33154553
Herbs and dietary supplement-induced liver injury (HILI) is the leading cause of drug-induced liver injury in China. Among different hepatotoxic herbs, the pyrrolizidine alkaloid (PA)-producing herb Gynura japonica contributes significantly...
13.
1-Formyl-7-hydroxy-6,7-dihydro-5-pyrrolizine (1-CHO-DHP)-Cysteine Conjugates: Metabolic Formation and Binding to Cellular DNA
He X, Xia Q, Zhao Y, Fu P
Chem Res Toxicol . 2020 Jun; 33(8):2139-2146. PMID: 32588618
1-Formyl-7-hydroxy-6,7-dihydro-5-pyrrolizine (1-CHO-DHP) is a potential proximate carcinogenic metabolite of pyrrolizidine alkaloids. In the present study, we determined that the reaction of 1-CHO-DHP with cysteine generated four identified products. By mass...
14.
Pulmonary toxicity is a common phenomenon of toxic pyrrolizidine alkaloids
Song Z, He Y, Ma J, Fu P, Lin G
J Environ Sci Health C Toxicol Carcinog . 2020 Jun; 38(2):124-140. PMID: 32500835
The hepatotoxic pyrrolizidine alkaloids (PAs) are metabolically activated in the liver to form reactive dehydro-PAs, which generate pyrrole-protein adducts leading to hepatotoxicity. Monocrotaline, but not other PAs, is also pneumotoxic,...
15.
Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes
He X, Xia Q, Shi Q, Fu P
J Environ Sci Health C Toxicol Carcinog . 2020 Jun; 38(2):109-123. PMID: 32500832
Pyrrolizidine alkaloids (PAs) are hepatotoxic, genotoxic, and carcinogenic phytochemicals. Upon metabolic activation, PAs produce dehydropyrrolizidine alkaloids (dehydro-PAs) as reactive primary pyrrolic metabolites. Dehydro-PAs are unstable, facilely hydrolyzed to (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5-pyrrolizine (DHP)....
16.
Platinum nanoparticles inhibit antioxidant effects of vitamin C via ascorbate oxidase-mimetic activity
Chen C, Fan S, Li C, Chong Y, Tian X, Zheng J, et al.
J Mater Chem B . 2020 Apr; 4(48):7895-7901. PMID: 32263780
The development and application of nanomaterials as consumer products including food, drugs, and cosmetics are rapidly expanding. However, interactions between these novel materials and other chemical components of consumer products...
17.
Quantitation of DNA reactive pyrrolic metabolites of senecionine - A carcinogenic pyrrolizidine alkaloid by LC/MS/MS analysis
Xia Q, He X, Shi Q, Lin G, Fu P
J Food Drug Anal . 2019 Dec; 28(1):167-174. PMID: 31883605
Pyrrolizidine alkaloids (PAs) are carcinogenic phytochemicals, inducing liver tumors in experimental rodents. We previously determined that (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP), 7-glutathione-DHP, 7-cysteine-DHP, 7-N-acetylcysteine-DHP, and 1-CHO-DHP are DNA reactive pyrrolic metabolites potentially associated...
18.
Influences of simulated gastrointestinal environment on physicochemical properties of gold nanoparticles and their implications on intestinal epithelial permeability
Jiang X, Zhang X, Gray P, Zheng J, Croley T, Fu P, et al.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev . 2019 Jun; 37(2):116-131. PMID: 31230526
Gold nanoparticles (Au NPs) hold great promise in food, industrial and biomedical applications due to their unique physicochemical properties. However, influences of the gastrointestinal tract (GIT), a likely route for...
19.
Separation of charge carriers and generation of reactive oxygen species by TiO nanoparticles mixed with differently-coated gold nanorods under light irradiation
Zhang H, Meng D, Fu B, Fan H, Cai R, Fu P, et al.
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev . 2019 May; 37(2):81-98. PMID: 31131702
Combinations of semiconductor nanoparticles (NPs) with noble metal NPs enable an increase in the photoactivity of semiconductor NPs into the visible and near-infrared regions. The design rationale of the semiconductor-metal...
20.
1-Formyl-7-hydroxy-6,7-dihydro-5 H-pyrrolizine (1-CHO-DHP): A Potential Proximate Carcinogenic Metabolite of Pyrrolizidine Alkaloids
He X, Xia Q, Gamboa da Costa G, Lin G, Fu P
Chem Res Toxicol . 2019 May; 32(6):1193-1203. PMID: 31120748
Pyrrolizidine alkaloids (PAs) are phytochemicals present in more than 6000 plant species worldwide; about half of the PAs are hepatotoxic, genotoxic, and carcinogenic. Because of their wide exposure and carcinogenicity,...