Paul C Howard
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Explore the profile of Paul C Howard including associated specialties, affiliations and a list of published articles.
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55
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799
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Recent Articles
1.
Nelson C, Brown P, Fitzpatrick S, Ford K, Howard P, MacGill T, et al.
Science
. 2024 Nov;
386(6723):724-726.
PMID: 39541448
Emerging approaches show promise for regulatory use.
2.
Tang Y, Bryant M, Li M, Min S, Pellar G, Wu Q, et al.
Toxicol Sci
. 2024 Sep;
202(2):196-209.
PMID: 39270062
Nicotine is an alkaloid found in tobacco. Human exposure to nicotine primarily occurs through the use of tobacco products. To date, limited nicotine pharmacokinetic data in animals have been reported....
3.
Brown P, Hooberman B, Skinner B, Wrzesinski C, Petibone D, Ford K, et al.
ALTEX
. 2024 Aug;
PMID: 39133010
Microphysiological systems (MPS) are designed to recapitulate aspects of tissue/organ physiology in vivo, thereby providing potential value in safety and efficacy assessments of FDA-regulated products and regulatory decision-making. While there...
4.
Hu S, Min S, Kang H, Yang D, Basavarajappa M, Lewis S, et al.
Food Chem Toxicol
. 2021 Dec;
160:112780.
PMID: 34965465
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the key tobacco-specific nitrosamines that plays an important role in human lung carcinogenesis. Repeated dose inhalation toxicity data on NNK, particularly relevant to cigarette smoking,...
5.
Hu S, Min S, Kang H, Yang D, Lewis S, Davis K, et al.
Toxicol Sci
. 2021 Jul;
183(2):319-337.
PMID: 34329464
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the key tobacco-specific nitrosamines that plays an important role in human lung carcinogenesis. However, repeated inhalation toxicity data on NNK, which is more directly relevant...
6.
Hu S, Bryant M, Sepehr E, Kang H, Trbojevich R, Lagaud G, et al.
Toxicol Sci
. 2021 May;
182(1):10-28.
PMID: 33944952
The tobacco-specific nitrosamine NNK [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone] is found in tobacco products and tobacco smoke. NNK is a potent genotoxin and human lung carcinogen; however, there are limited inhalation data for the...
7.
Finding the bad actor: Challenges in identifying toxic constituents in botanical dietary supplements
Roberts G, Gardner D, Foster P, Howard P, Lui E, Walker L, et al.
Food Chem Toxicol
. 2018 Dec;
124:431-438.
PMID: 30582954
Botanical-derived dietary supplements have widespread use in the general population. The complex and variable nature of botanical ingredients and reports of adverse responses have led to concern for negative human...
8.
Eustaquio T, Wang C, Dugard C, George N, Liu F, Slikker Jr W, et al.
Exp Cell Res
. 2018 Oct;
373(1-2):164-170.
PMID: 30342004
Ketamine, an FDA-approved N-methyl-D-aspartate (NMDA) receptor antagonist, is commonly used for general pediatric anesthesia. Accumulating evidence has indicated that prolonged exposure to ketamine induces widespread apoptotic cell death in the...
9.
Khan S, Zhang Q, Marasa B, Sung K, Cerniglia C, Ingle T, et al.
Nanomedicine (Lond)
. 2017 Aug;
12(17):2097-2111.
PMID: 28805153
Aim: The goal of this study was to determine whether bacterial clearance in a rodent model would be impaired upon exposure to gold, silver or silica nanoparticles (NPs). Materials &...
10.
Weaver J, Tobin G, Ingle T, Bancos S, Stevens D, Rouse R, et al.
Part Fibre Toxicol
. 2017 Jul;
14(1):25.
PMID: 28716104
Background: As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study...